Most Read Articles
5 days ago
Eating red meat may lead to cardiovascular (CV) target organ damage over a 4-year period, according to a recent study involving hypertensive American Indians.
5 days ago
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.
Jairia Dela Cruz, 2 days ago
Capecitabine appears to provide additional survival benefit in triple-negative breast cancer patients treated with standard chemotherapy, significantly improving disease-free survival and overall survival but potentially increasing adverse events consistent with the drug’s known toxicity profile, according to a meta-analysis.

Low lean mass predicts fracture risk in Korean males

06 Aug 2017

Low lean mass (LM), either alone or in combination with high percentage fat mass (PF), increases the risk of fragility in Korean males, a new study shows. In Korean females, body composition does not appear to be associated with fracture risk.

Body compositions of 2,189 males and 2,625 females from the Ansung cohort study were measured using bioelectrical impedance analysis. Self-reported questionnaires were used to assess fractures excluding high-trauma fractures. Patients with malignancies or who had taken drugs that may have affected bone metabolism were excluded.

Over a follow-up period of 9.4 years, 3.5 percent (n=77) of male and 7.7 percent (n=203) of female participants had fractures.

Compared with males without fractures, weight (65.4±9.9 vs 61.2±8.8 kg; p<0.001), BMI (23.8±3.0 vs 22.2±2.8 kg/m2; p<0.001), LM (48.6±6.5 vs 46.1±6.5 kg; p=0.001) and fat mass (13.9±5.1 vs 12.4±4.6 kg; p=0.009) were all significantly lower in males with fractures.

Females with fractures had significantly lower height (55.1±9.0 vs 59.2±7.5 cm; p<0.001) and LM (37.6±4.7 vs 36.5±4.1 kg; p=0.001) than females with fractures.

Compared with males with normal LM and PF, males with low LM and normal PF (hazard ratio [HR], 2.16; 95 percent CI, 1.13 to 4.16) and those with low LM and high PF (HR, 2.59; 1.13 to 5.95) had higher risk of fractures. Males with normal LM and high PF did not have an elevated risk of fractures (HR, 0.71; 0.38 to 1.31).

The risk of fractures in females with low LM and normal PF (HR, 1.14; 0.72 to 1.79), with low LM and high PF (HR, 1.03; 0.49 to 2.19), and with normal LM and high PF (HR, 1.33; 0.95 to 1.87) were only slightly higher than those with normal LM and PF.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
5 days ago
Eating red meat may lead to cardiovascular (CV) target organ damage over a 4-year period, according to a recent study involving hypertensive American Indians.
5 days ago
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.
Jairia Dela Cruz, 2 days ago
Capecitabine appears to provide additional survival benefit in triple-negative breast cancer patients treated with standard chemotherapy, significantly improving disease-free survival and overall survival but potentially increasing adverse events consistent with the drug’s known toxicity profile, according to a meta-analysis.