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Low lean mass predicts fracture risk in Korean males

06 Aug 2017

Low lean mass (LM), either alone or in combination with high percentage fat mass (PF), increases the risk of fragility in Korean males, a new study shows. In Korean females, body composition does not appear to be associated with fracture risk.

Body compositions of 2,189 males and 2,625 females from the Ansung cohort study were measured using bioelectrical impedance analysis. Self-reported questionnaires were used to assess fractures excluding high-trauma fractures. Patients with malignancies or who had taken drugs that may have affected bone metabolism were excluded.

Over a follow-up period of 9.4 years, 3.5 percent (n=77) of male and 7.7 percent (n=203) of female participants had fractures.

Compared with males without fractures, weight (65.4±9.9 vs 61.2±8.8 kg; p<0.001), BMI (23.8±3.0 vs 22.2±2.8 kg/m2; p<0.001), LM (48.6±6.5 vs 46.1±6.5 kg; p=0.001) and fat mass (13.9±5.1 vs 12.4±4.6 kg; p=0.009) were all significantly lower in males with fractures.

Females with fractures had significantly lower height (55.1±9.0 vs 59.2±7.5 cm; p<0.001) and LM (37.6±4.7 vs 36.5±4.1 kg; p=0.001) than females with fractures.

Compared with males with normal LM and PF, males with low LM and normal PF (hazard ratio [HR], 2.16; 95 percent CI, 1.13 to 4.16) and those with low LM and high PF (HR, 2.59; 1.13 to 5.95) had higher risk of fractures. Males with normal LM and high PF did not have an elevated risk of fractures (HR, 0.71; 0.38 to 1.31).

The risk of fractures in females with low LM and normal PF (HR, 1.14; 0.72 to 1.79), with low LM and high PF (HR, 1.03; 0.49 to 2.19), and with normal LM and high PF (HR, 1.33; 0.95 to 1.87) were only slightly higher than those with normal LM and PF.

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Most Read Articles
Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
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