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Low-fat dietary pattern may improve breast cancer survival

07 Oct 2017

Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.

The trial randomly assigned 48,835 postmenopausal women with normal mammograms and had no prior breast cancer to a dietary intervention with goals of reducing fat intake to 20 percent of energy and increasing consumption of fruits, vegetables and grains (n=19,541), or to a usual diet comparison (n=29,294).

A total of 1,764 incident breast cancers were reported during the 8.5-year dietary intervention. Fewer breast cancer-related deaths occurred in the low-fat diet group than in the usual diet group (27 vs 61 deaths; hazard ratio [HR], 0.67; 95 percent CI, 0.43 to 1.06), although the difference was not significant (p=0.08). On the other hand, the number of deaths after breast cancer significantly differed, in favour of the low-fat diet group (40 vs 94 deaths; HR, 0.65; 0.45 to 0.94; p=0.02).

During the 16.1-year follow-up, with 3,030 incident breast cancers, the number of deaths after breast cancer was also significantly lower in the low-fat vs usual diet group (234 vs 443 deaths; HR, 0.82; 0.70 to 0.96; p=0.01).

Participants who followed a low-fat dietary pattern particularly achieved a significant reduction in fat intake and body weight (p<0.001 for all).

Dietary intervention through a low-fat diet is believed to restore insulin sensitivity and reverse insulin's tumour-promoting effects, given that insulin resistance commonly results from obesity. Previous studies have shown that chronically increased concentrations of insulin may induce tumour growth and that insulin resistance may promote breast cancer development. [Am J Clin Nutr 2007;86:878S-881S]

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Most Read Articles
Roshini Claire Anthony, 16 Oct 2017

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.