Low-energy diet helps maintain long-term weight loss in obese patients with knee osteoarthritis
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
Researchers randomized 153 participants (mean age 63.8 years; mean body mass index, 33.3 kg/m2; 83 percent women) to either the intermittent treatment (IN) group with LED for 5 weeks every 4 months for 3 years (n=76) or to daily meal replacement of one to two meals for 3 years (regular [RE] group; n=77). Attention by dietitians and the amount of formula products were similar.
The participants were recruited between June and December 2009 from the osteoarthritis outpatient clinic at Copenhagen University Hospital in Frederiksberg, Denmark. They had previously completed a 68-week lifestyle intervention trial and lost an average of 10.5 kg or 10 percent of their initial body weight.
Changes in body weight and proportion of participants receiving knee replacements were the primary endpoints, which were analysed on the intention-to-treat population using baseline-carried-forward imputation for missing data.
Of the participants, 53 in the IN group and 56 in the RE group completed the trial. Weight increased by 0.68 kg in the IN group and by 1.75 kg in the RE group (mean difference, ‒1.06 kg; 95 percent CI, ‒2.75 to 0.063; p=0.22). The rates of alloplasty were low and did not differ in both groups (IN group: eight of 76 participants; RE group: 12 of 77 participants; p=0.35).
“These results challenge the commonly held assumption that weight regain in the long term is inevitable,” researchers said.