Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Low-dose calcium supplementation may reduce the risk of preeclampsia

13 Feb 2015

Although epidemiological studies have linked low dietary calcium intake with preeclampsia, current guidelines recommend supplementation with 1.5–2 g/day, which may be risky as this level of supplementation exceeds the recommended daily allowance of 1–1.3 g/day. However, a recent systematic review suggests that supplementation with lower doses of calcium (<1 g/day) may be sufficient to reduce the risk.

The investigators searched PubMed and the Cochrane Pregnancy and Childbirth Group trials register, and identified nine eligible trials that assessed the effects of supplementation with low-dose calcium, either alone or in combination with other supplements. Collectively, these involved 2,234 women.

The relative risk (RR) of preeclampsia was consistently reduced with low-dose calcium supplementation, irrespective of whether this was alone or in combination with other supplements (RR 0.38, 95% confidence interval [CI] 0.28–0.52). Subgroup analyses supported this finding, including the analyses for low-dose calcium alone (RR 0.36, 95% CI 0.23–0.57) or in combination with linoleic acid (RR 0.23, 95% CI 0.09–0.60) or vitamin D (RR 0.49, 0.31–0.78). A trend towards a reduced risk was also observed for the combination of low-dose calcium and antioxidants (RR 0.24, 95% CI 0.06–1.01).

The researchers concluded that further randomised controlled trials are required to confirm these findings, which could have global implications and may change current guideline recommendations.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.