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Low daily salt intake tied to improved BP control

Elaine Soliven
11 Oct 2017

Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.

The researchers analysed 10,547 patients with hypertension (mean age 64.5 years, 70.8 percent male, mean BP 130.9/78.2 mm Hg) who were taking antihypertensive medications and visited the hospital for a physical check-up over a 6-year period. Participants were divided into three groups according to the number of prescribed antihypertensive drugs: group 1 (n=5,469; one drug), group 2 (n=3,861; two drugs), and group 3 (n=1,217; ≥3 drugs). Spot urine method was used to estimate salt intake, and patients were assessed for up to 6 years. [APCH 2017, abstract 4665]

Overall, BP levels reduced from 132.9/80.1 to 129.9/77.1 mm Hg and achievement of target BP (<140/90 mm Hg) increased from 65.4 to 76.4 percent over the study duration in all groups.

Individuals with a BP level below target value (<140/90 mm Hg) were more likely to achieve a higher rate of salt restriction (<6 grams daily) compared with those who had a BP level above the target value (3.9 percent vs 2.5 percent, 2.9 percent vs 2.3 percent, and 2.6 percent vs 1.4 percent in groups 1, 2, and 3, respectively).

Individuals who achieved salt restriction were more likely to reach the target BP than those who did not achieve salt restriction (overall, 82.0 percent vs 72.5 percent; 78.4 percent vs 74.1 percent, and 84.8 percent vs 74.7 percent in groups 1, 2, and 3, respectively).

However, achievement rate of salt restriction reduced with the number of antihypertensive drugs prescribed (3.5, 2.9, and 2.4 percent in groups 1, 2, and 3, respectively).

“The control of BP in individuals with antihypertensive medications was improved in the last 6 years,” said lead author Dr Hiroyuki Takase from the Department of Internal Medicine at Enshu Hospital in Hamamatsu, Japan. “However, salt restriction has not been successfully achieved especially in hypertensive patients with multiple antihypertensive medications.”

“Excess salt intake may induce resistance to antihypertensive treatment and, thus, increases the number of antihypertensive drugs for BP control,” Takase added.
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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
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