Most Read Articles
16 Sep 2015
Brentuximab showed potential as an alternative front-line treatment for patients with Hodgkin lymphoma  aged ≥ 60 years who cannot tolerate standard combination chemotherapy in a phase II, open-label study.
27 Dec 2015
According to review article, photodynamic therapy can be considered as an alternative treatment for retinoblastoma due to its non-mutagenic character.
01 May 2017
Body mass index (BMI), body fat and waist circumference are highly correlated, and all show an association with aggressive prostate cancer, according to a study.
Fiel Soliven, 18 Mar 2015
The connection between prediabetes, diabetes, and risk of hepatocellular carcinoma (HCC) in HBsAg and anti-HCV seronegative patients, as well as the association between fasting glucose and HCC were examined in this study.

Long interval from diagnosis to treatment tied to poor outcomes in OCSSC

18 Apr 2017

A long interval between the confirmation of malignancy and the initiation of first treatment appears to be associated with a higher risk of death in patients with oral cavity squamous cell carcinoma (OCSSC), a new study shows.

The study retrieved the records of 21,263 patients with oral cavity cancers or SCC from the National Health Insurance Research Database of Taiwan. Those with multiple primary cancers, who had distant metastases, who died within 1 month and with incomplete information were excluded.

The time from diagnosis to the initiation of the first treatment was determined from the medical records. The primary outcome of the study was overall survival and the duration of follow-up was from diagnosis until death or withdrawal.

The average age at diagnosis was 53.5±12.0 years, and the average time interval from diagnosis to treatment was 24.3±76.3 days. Tongue cancer (35.9 percent) was the most common cancer type. Lip, gum and mouth floor cancers (19.9 percent), and cancers of the palate, buccal mucosa and unspecified sites (44.1 percent) were also reported.

The most common first treatment was surgery (93.1 percent), followed by radiotherapy (4.7 percent) and chemotherapy (2.2 percent). Only 2,498 (11.8 percent) and 572 patients (2.7 percent) received treatment between 31 and 120 days, and 120 days after diagnosis, respectively. The vast majority (85.6 percent) received treatment within 30 days.

There was a significant difference between the number of survivors (n=12,417) and that of deaths (n=8,846; p<0.001). Patients who received treatment within 30 days had a higher survival rate than those treated after 120 days (60.4 vs 35.8 percent).

Finally, patients who received treatment after 120 days are 1.32 (95 percent CI, 1.19 to 1.47) times more at risk of death compared with those who received treatment within 30 days.

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Most Read Articles
16 Sep 2015
Brentuximab showed potential as an alternative front-line treatment for patients with Hodgkin lymphoma  aged ≥ 60 years who cannot tolerate standard combination chemotherapy in a phase II, open-label study.
27 Dec 2015
According to review article, photodynamic therapy can be considered as an alternative treatment for retinoblastoma due to its non-mutagenic character.
01 May 2017
Body mass index (BMI), body fat and waist circumference are highly correlated, and all show an association with aggressive prostate cancer, according to a study.
Fiel Soliven, 18 Mar 2015
The connection between prediabetes, diabetes, and risk of hepatocellular carcinoma (HCC) in HBsAg and anti-HCV seronegative patients, as well as the association between fasting glucose and HCC were examined in this study.