Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.

Liver function associated with metabolic syndrome risk

22 Mar 2017

The risk of metabolic syndrome (MS) is associated with liver function in a Chinese population. Age and gender influence this association, a new study shows.

The cross-sectional study involved 32,768 individuals (20,643 males) who self-reported as healthy. Those who had histories of liver disease, were taking medication that may affect liver function, were pregnant and had malignant diseases were excluded.

Levels of total bilirubin (TBIL), alanine aminotransferase (ALT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), elevated triglycerides (TG), blood urea nitrogen (BUN), uric acid (UA), creatinine (Cr) and fasting glucose (FG) were measured.

Of the 32,768 patients, 10,654 (32.51 percent) had MS; 37.72 percent of males had MS compared to 23.65 percent of females (p<0.01). In both males and females, MS incidence showed an increasing trend with age until 45 to 55 years.

In males, age was positively associated with LDL, HDL, FG, Cr, BUN, TC, waist circumference (WC), systolic blood pressure (SBP) and diastolic blood pressure (DBP), and negatively correlated with gamma glutamyltransferase (GGT), ALT, TG and UA. In females, on the other hand, age was negatively correlated only with HDL.

Both males (odds ratio [OR], 0.814; 95 percent CI, 0.743 to 0.891; OR, 0.673; 0.613 to 0.739; p<0.01 for both) and females (OR, 0.761; 0.661 to 0.875; OR, 0.753; 0.653 to 0.867; p<0.01 for both) in the third and fourth TBIL quartiles, respectively, were at a lower risk of MS.

Conversely, both males (OR, 1.710; 1.546 to 1.892; OR, 2.438; 2.202 to 2.700; OR, 3.715; 3.335 to 4.138; p<0.01 for all) and females (OR, 1.730; 1.458 to 2.052; OR, 2.425; 2.048 to 2.871; OR, 3.027; 2.552 to 3.592; p<0.01 for all) in the second to fourth GGT quartiles were at a higher risk of developing MS. Finally, ALT and age quartiles also showed significant increases in the risk of MS.

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Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.