Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Liver fibrosis indices predict portal hypertension in cirrhotic patients

05 Sep 2017
Serum indices of liver fibrosis show moderate diagnostic accuracy for portal hypertension (PH) in cirrhotic patients, reveals a recent study.

In a study cohort of 238 liver cirrhosis patients (mean age 52.55±10.44 years), 78.99 percent (n=188) had clinically significant PH (CSPH) while 68.49 percent (n=163) had severe PH (SPH).

Multivariate analysis showed that aminotransferase (AST; odds ratio [OR], 1.033; 95 percent CI, 1.031 to 1.034; p=0.005), platelet (PLT) count (OR, 0.993; 0.990 to 0.995; p=0.002) and albumin (OR, 0.943; 0.940 to 0.947; p=0.026) were independently and significantly associated with hepatic venous pressure gradient (HVPG) grade.

The resulting HVPG prediction model yielded areas under the curve (AUCs) of 0.780 (0.722 to 0.831) and 0.769 (0.711 to 0.821) for the prediction of CSPH and SPH, respectively. The corresponding sensitivities were 68.62 and 69.33 percent, while the specificities were 80.0 and 74.67 percent, respectively.

Of the live fibrosis indices used, King’s score (AUC, 0.755), AST-to-PLT ratio index (APRI; AUC, 0.742) and Lok index (AUC, 0.740) had the best diagnostic performance for CSPH. APRI showed the highest accuracy (76.89 percent), while King’s score was significantly better than FIB-4 (p=0.0002) and Forns index (p=0.0002).

For SPH, receiver operating curve analysis showed that King’s score (AUC, 0.742), APRI (AUC, 0.722) and Lok index (AUC, 0.717) again had the best diagnostic performance. Lok index had the highest accuracy (68.91 percent).

Lok index and King’s score were then combined. The resulting diagnostic performance outcome for CSPH was a 52.7 percent sensitivity and 90.4 percent specificity. For SPH, the sensitivity of the model was 34.55 percent while its specificity was 94.7 percent.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.