Most Read Articles
Jackey Suen, 19 May 2016
Researchers from The University of Hong Kong have developed a probiotic mixture that has been shown to suppress cancer growth in extraintestinal regions such as the liver. [Proc Natl Acad Sci U S A 2016;113:E1306-E1315]
Elvira Manzano, 22 Apr 2016
Patients infected with hepatitis C virus (HCV) who are in need of a transplant can safely receive a liver from an HCV-positive donor with a healthy liver biopsy, according to an analysis of outcomes spanning over 18 years.
Pank Jit Sin, 17 Apr 2015
Diagnosis and treatment of NAFLD isn’t always precise, but new developments are helping to pave the way for better management of the disease, shares a panel of experts. 
26 Apr 2016
Patients using aspirin are up to 3.6 times less likely to develop cholangiocarcinoma (CCA) compared with those unexposed to the drug, according to a recent US cohort study.

Liver cirrhosis ups gallstone risk in Chinese patients with chronic HCV

29 Aug 2017
Those with a history of gallstone disease have a 23% increased risk for coronary heart disease.

Liver cirrhosis is significantly correlated with higher risk of gallstones in Chinese patients with chronic hepatitis C virus (HCV) infection, a new retrospective case-control study has found.

The study included 133 (mean age 60.04 years) patients with chronic HCV and gallstones recruited from the Hospital of Jilin University in China. Those who were infected by HIV or HBV, had histories of cancer or had other liver diseases were excluded.

Liver cirrhosis was diagnosed based on liver biopsies or batteries of clinical, radiological and biochemical tests. The Child-Pugh score was used to determine cirrhosis severity. Multivariate logistic regressions were used to determine the association between liver cirrhosis and gallstones in chronic HCV.

Compared to chronic HCV patients without gallstone controls (n=431; mean age 59.06 years; 50.8 percent male), there were significantly more patients with liver cirrhosis in the gallstones group (24.4 vs 40.6 percent; p<0.001).

Additionally, significantly more chronic CHV patients with gallstones were aged >60 years compared with the no gallstones group (37.6 vs 47.4 percent; p=0.044).

Multivariable analysis showed that the presence of liver cirrhosis significantly elevated the risk of gallstones in chronic HCV (adjusted odds ratio [aOR], 2.122; 95 percent CI, 1.408 to 3.198; p<0.001).

Moreover, the risk of gallstones was significantly higher in decompensated liver cirrhosis patients (Child Pugh class B and C) than in those with compensated liver cirrhosis (Child Pugh class A; aOR, 2.869; 1.277 to 6.450; p=0.011).

Liver cirrhosis patients aged >60 years also had higher risk of gallstones (aOR, 2.019; 1.017 to 4.009; p=0.045).

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Most Read Articles
Jackey Suen, 19 May 2016
Researchers from The University of Hong Kong have developed a probiotic mixture that has been shown to suppress cancer growth in extraintestinal regions such as the liver. [Proc Natl Acad Sci U S A 2016;113:E1306-E1315]
Elvira Manzano, 22 Apr 2016
Patients infected with hepatitis C virus (HCV) who are in need of a transplant can safely receive a liver from an HCV-positive donor with a healthy liver biopsy, according to an analysis of outcomes spanning over 18 years.
Pank Jit Sin, 17 Apr 2015
Diagnosis and treatment of NAFLD isn’t always precise, but new developments are helping to pave the way for better management of the disease, shares a panel of experts. 
26 Apr 2016
Patients using aspirin are up to 3.6 times less likely to develop cholangiocarcinoma (CCA) compared with those unexposed to the drug, according to a recent US cohort study.