Liver cirrhosis ups gallstone risk in Chinese patients with chronic HCV
Liver cirrhosis is significantly correlated with higher risk of gallstones in Chinese patients with chronic hepatitis C virus (HCV) infection, a new retrospective case-control study has found.
The study included 133 (mean age 60.04 years) patients with chronic HCV and gallstones recruited from the Hospital of Jilin University in China. Those who were infected by HIV or HBV, had histories of cancer or had other liver diseases were excluded.
Liver cirrhosis was diagnosed based on liver biopsies or batteries of clinical, radiological and biochemical tests. The Child-Pugh score was used to determine cirrhosis severity. Multivariate logistic regressions were used to determine the association between liver cirrhosis and gallstones in chronic HCV.
Compared to chronic HCV patients without gallstone controls (n=431; mean age 59.06 years; 50.8 percent male), there were significantly more patients with liver cirrhosis in the gallstones group (24.4 vs 40.6 percent; p<0.001).
Additionally, significantly more chronic CHV patients with gallstones were aged >60 years compared with the no gallstones group (37.6 vs 47.4 percent; p=0.044).
Multivariable analysis showed that the presence of liver cirrhosis significantly elevated the risk of gallstones in chronic HCV (adjusted odds ratio [aOR], 2.122; 95 percent CI, 1.408 to 3.198; p<0.001).
Moreover, the risk of gallstones was significantly higher in decompensated liver cirrhosis patients (Child Pugh class B and C) than in those with compensated liver cirrhosis (Child Pugh class A; aOR, 2.869; 1.277 to 6.450; p=0.011).
Liver cirrhosis patients aged >60 years also had higher risk of gallstones (aOR, 2.019; 1.017 to 4.009; p=0.045).