Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

LCN, SCN provide safe outcomes in osteoporotic pertrochanteric fractures

Stephen Padilla
15 Mar 2017

Both long (LCN) and short cephalomedullary nails (SCN) deliver safe and reliable outcomes in the treatment of osteoporotic pertrochanteric fractures, with no significant difference in terms of complications, revision surgeries, union rates and ambulatory statuses among patients, according to a Singapore study.

Researchers performed a retrospective review of 64 patients (mean age 79.9 years; 45 female; 38 had a left-sided hip injury) with osteoporotic pertrochanteric fractures who were treated with either LCN or SCN and had a minimum follow-up of 1 year. Based on the Orthopaedic Trauma Association (OTA) classification, 15 patients had OTA Class 31-A1 fractures and 49 had OTA Class 31-A2 fractures. All of the patients were osteoporotic, with an average T-score of ‒3.45 (range, ‒2.6 to ‒5.4).

Complications, revision surgeries and union rates were the primary outcome measures. Secondary outcome measures included duration of surgery, estimated blood loss, length of hospital stay, and ambulatory and mortality status at 1 year.

There were no significant differences in the clinical and functional outcomes of patients who were treated with LCN or SCN. However, those treated with SCN had a higher incidence of heterotopic ossification, while those who received LCN had a slightly higher average estimated blood loss and duration of surgery. In addition, patients treated with LCN appeared to be more osteoporotic. [Singapore Med J 2017; 58:85-91]

“This finding is in keeping with other studies in the literature,” researchers said. “For example, a study by Hou et al, which reviewed 283 patients who underwent either short or long cephalomedullary nail insertion for pertrochanteric fractures (ie, OTA Class 31-A1 and Class 31-A2 fractures), reported no significant difference in the complication or union rates between the two groups.” [J Orthop Trauma 2013;27:318-24]

No difference was also observed in the development of periprosthetic fractures between LCN and SCN despite the additional risk of periprosthetic fracture at the tip of short nails, particularly in osteoporotic bones. However, all three cases of periprosthetic fracture occurred in the SCN cohort. Of these, one case was fractured distal to the tip of the short nail, while the other two cases were fractured around the trochanteric region and the distal femur supracondylar region.

“Previous studies have hypothesised that short nails were more likely to create diaphyseal stress risers at the tip, causing periprosthetic fractures,” researchers said. “However, newer implants with better designs, such as lower modulus elasticity (eg, titanium), more anatomical femoral bow, tapered tips and smaller distal locking screws, have been developed to address this issue.” [J Bone Joint Surg Am 2009;91:712-9; J Bone Miner Res 1994;9:1137-41]

The current study was limited by its retrospective nature, the relatively smaller cohort of patients, lack of a longer-term follow-up and the results that were generated from a single centre, they added.

Osteoporosis is a condition that affects the global population, specifically women, and is associated with several complications such as hip fracture. Studies have projected that by 2050, potentially 50 percent of all hip fractures in the world will occur in Asia and Latin America, where osteoporosis is most prevalent. [Osteoporos Int 2006;17:1726-33; Osteoporos Int 1992;2:285-9]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.