Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Lateral wedge arch support does not reliably reduce knee load in medial knee osteoarthritis

23 Jul 2017
Lateral wedge arch support (LWAS) insoles are not beneficial in reducing knee load in patients with medial knee osteoarthritis, reveals a new meta-analysis.

A meta-analysis of nine studies (n=337) showed an overall pooled reduction in the first peak external knee adduction moments (EKAM; standard mean difference [SMD], -0.22; 95 percent CI, -0.37 to -0.07; p=0.005) due to LWAS.

On the other hand, subgroup analyses showed that LWAS significantly improved first peak EKAM when compared against neutral insoles (SMD, -0.27; -0.51 to -0.04; p=0.02) but not against control shoes (SMD, -0.17; -0.37 to 0.03; p=0.10) or flat insoles (SMD, -0.39; -1.28 to 0.49; p=0.39)

LWAS also showed an overall significant reduction in second peak EKAM (SMD, -0.26; -0.47 to -0.06; p=0.01) according to a meta-analysis of four studies.

However, subsequent subgroup analysis showed that LWAS improved second peak EKAM only against the shoe-only control (SMD, -0.25; -0.48 to 0.17; p=0.03) and not against neutral insoles (SMD, -0.30; -0.76 to 0.17; p=0.21).

Knee adduction angular impulse (KAAI) was analysed in six studies. Overall pooled estimates showed significant declines in KAAI using LWAS (SMD, -0.21; -0.39 to -0.02; p=0.03).

Subsequent subgroup analyses again showed no statistically significant improvements in KAAI as a result of LWAS use compared with neutral insoles (SMD, -0.23; -0.61 to 0.15; p=0.23) or shoe-only controls (SMD, -0.20; -0.41 to 0.01; p=0.06).

The meta-analysis included articles that compared the efficacy of LWAS against controls (control shoe, neutral insole or flat insole) in adults with medial knee osteoarthritis. The databases of Google Scholar, Cochrane Library, Wiley Online Library, Web of Science, Embase and Medline were accessed. Quality of the studies was assessed using the Quality Index.

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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.