Most Read Articles
Pearl Toh, 01 Aug 2016
Understanding biomarkers predictive of treatment outcomes or response can help inform treatment decisions and personalize care for advanced prostate cancer patients, suggested an expert at the recent Urological Association of Asia Annual Congress (UAA 2016) held in Singapore.
Roshini Claire Anthony, 07 Jun 2017

The addition of pertuzumab to standard-of-care therapy may convey a positive, albeit modest, effect for women with HER2-positive breast cancer, according to findings from the APHINITY* trial presented at the annual meeting of the American Society of Clinical Oncology (ASCO 2017) held in Chicago, Illinois, US.

Jackey Suen, 30 Jun 2015
The American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO) have developed new approaches to assist oncologists in evaluating anticancer regimens available in the market.
16 Nov 2015
Difficulties in verbal fluency and comprehension were usually experienced by adolescents with Sydenham chorea, a study has shown.

Lactate dehydrogenase, creatinine kinase predict survival, poor prognosis in lung cancer

12 Sep 2017

Similar to their role in other cancers, plasma concentrations of lactate dehydrogenase (LDH) and creatinine kinase (CK) are independent predictors of survival and poor prognosis in lung cancer patients, particularly those with adenocarcinoma, a new study reveals.

The study included 1,142 lung cancer patients (69.2 percent male), of which 678 were positive for CK and 464 were negative, with respect to cut-off values. In comparison, 410 were LDH positive and 732 were negative.

In lung adenocarcinoma patients (n=608), bone metastasis was significantly more common in CK-negative than in CK-positive patients (27.6 vs 19.4 percent; p<0.05), while a stage four disease was significantly more common in in LDH-positive than in LDH-negative patients (72.5 vs 57.2 percent; p<0.05).

Elevated LDH levels were also significantly associated with metastasis to the bone (p<0.001), liver (p<0.001) and adrenal gland (p<0.001).

On the other hand, squamous cell carcinoma patients (n=307) that were positive for CK showed lower bone metastasis compared to those who were negative (6.8 vs 16.8 percent). Metastasis to other regions was not related to CK levels. LDH level was not significantly associated with any of the clinical characteristics.

In all lung cancer patients, lower plasma CK was associated with significantly poorer overall survival status (p<0.001), while higher LDH levels were linked to significantly poorer outcomes (p<0.001).

In those with adenocarcinoma, lower CH and higher LDH were associated with poor survival status (p<0.001 for both), while in squamous cell carcinoma patients, only CK concentration was tied to survival (p<0.05).

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Most Read Articles
Pearl Toh, 01 Aug 2016
Understanding biomarkers predictive of treatment outcomes or response can help inform treatment decisions and personalize care for advanced prostate cancer patients, suggested an expert at the recent Urological Association of Asia Annual Congress (UAA 2016) held in Singapore.
Roshini Claire Anthony, 07 Jun 2017

The addition of pertuzumab to standard-of-care therapy may convey a positive, albeit modest, effect for women with HER2-positive breast cancer, according to findings from the APHINITY* trial presented at the annual meeting of the American Society of Clinical Oncology (ASCO 2017) held in Chicago, Illinois, US.

Jackey Suen, 30 Jun 2015
The American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO) have developed new approaches to assist oncologists in evaluating anticancer regimens available in the market.
16 Nov 2015
Difficulties in verbal fluency and comprehension were usually experienced by adolescents with Sydenham chorea, a study has shown.