Most Read Articles
Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.

Lactate dehydrogenase, creatinine kinase predict survival, poor prognosis in lung cancer

12 Sep 2017

Similar to their role in other cancers, plasma concentrations of lactate dehydrogenase (LDH) and creatinine kinase (CK) are independent predictors of survival and poor prognosis in lung cancer patients, particularly those with adenocarcinoma, a new study reveals.

The study included 1,142 lung cancer patients (69.2 percent male), of which 678 were positive for CK and 464 were negative, with respect to cut-off values. In comparison, 410 were LDH positive and 732 were negative.

In lung adenocarcinoma patients (n=608), bone metastasis was significantly more common in CK-negative than in CK-positive patients (27.6 vs 19.4 percent; p<0.05), while a stage four disease was significantly more common in in LDH-positive than in LDH-negative patients (72.5 vs 57.2 percent; p<0.05).

Elevated LDH levels were also significantly associated with metastasis to the bone (p<0.001), liver (p<0.001) and adrenal gland (p<0.001).

On the other hand, squamous cell carcinoma patients (n=307) that were positive for CK showed lower bone metastasis compared to those who were negative (6.8 vs 16.8 percent). Metastasis to other regions was not related to CK levels. LDH level was not significantly associated with any of the clinical characteristics.

In all lung cancer patients, lower plasma CK was associated with significantly poorer overall survival status (p<0.001), while higher LDH levels were linked to significantly poorer outcomes (p<0.001).

In those with adenocarcinoma, lower CH and higher LDH were associated with poor survival status (p<0.001 for both), while in squamous cell carcinoma patients, only CK concentration was tied to survival (p<0.05).

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Most Read Articles
Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.