L. gasseri OLL2716 beneficial for H. pylori-negative functional dyspepsia
Probiotics containing Lactobacillus gasseri (L. gasseri) OLL2716 may improve functional dyspepsia in Helicobacter pylori (H. pylori)-negative individuals, a new study has shown.
One hundred and six H. pylori-negative Japanese patients (mean age 42.8 years, 74.5 percent female) experiencing one or more of the four major dyspepsia symptoms (ie, postprandial fullness or early satiety [symptoms of postprandial distress syndrome], or epigastric pain or epigastric burning [symptoms of epigastric pain syndrome]) with symptoms untreated for ≥6 months prior to study entry were randomized to consume one unit (85 g) of yoghurt daily with (n=54) or without (placebo group, n=52) L. gasseri OLL2716 for 12 weeks. A global participant questionnaire was used to assess effect of yoghurt on gastric symptoms. [Digestion 2017;96:92-102]
L. gasseri OLL2716 consumption was associated with a more, albeit insignificant, improvement in gastric symptoms vs placebo (35.2 percent vs 23.1 percent for ‘improved’ patients and 11.1 percent vs 7.7 percent for ‘very much improved’ patients) at 12 weeks (p=0.073).
The rate of disappearance of all dyspepsia symptoms was also higher with L. gasseri OLL2716 vs placebo (35.2 percent vs 17.3 percent; p=0.048), with a more significant difference for patients with postprandial distress syndrome than epigastric pain syndrome (p=0.040 vs p=1.000) at 12 weeks.
At 8 weeks, individual symptom scores were also more improved with L. gasseri OLL2716 consumption than with placebo (p=0.042 for postprandial fullness, p=0.088 for early satiety, p=0.032 for epigastric bloating, p=0.020 for heartburn, and p=0.047 for reflex feeling of gastric acid).
The improvement in epigastric bloating was considered an important finding as this symptom is common among Asians with dyspepsia, said the researchers. [J Gastroenterol Hepatol 2012;27:626-641]
Given previous findings showing the presence of the intestinal bacteria Bifidobacterium and Clostridium in the gastric juice of individuals with functional dyspepsia, [BMJ Open Gastroenterol 2016;3:e000109] it is important to further evaluate the ability of L. gasseri OLL2716 to improve functional dyspepsia.
“L. gasseri OLL2716-specific characteristics such as … resistance to gastric acids, ability to grow at low pH, and ability to attach to gastric-derived cultured cells may be responsible for the demonstrated ameliorating effect on [functional dyspepsia],” said the researchers. “[However], there is a need to elucidate at which sites between the stomach and the intestine L. gasseri OLL2716 acts, and whether indigenous bacterial flora are involved in the process.”
Habitual yoghurt intake may be necessary to optimize the effect of L. gasseri OLL2716 on functional dyspepsia and maintain a healthy gut microbiota, though yoghurt consumption, even without L. gasseri OLL2716, may render improvement given the improved gastric mucosal permeability associated with probiotics, they said.