Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

IVZ injections improve eyes with non-AMD-related choroidal neovascularization

28 Sep 2017

Treatment with intravitreal ziv-aflibercept (IVZ) injections improves central macular thickness (CMT) in patients with choroidal neovascularization (CNV) associated with causes other than age-related macular degeneration (AMD), a recent study has found. However, improvements in best-corrected visual acuity (BCVA) are modest.

In this retrospective study, researchers included eyes with non-AMD-related CNV that were treated with IVZ (1.25 mg/0.05 mL) on a pro re nata basis. The mean change in BCVA was the primary outcome measure, and the secondary outcome measures were the mean change in CMT and adverse events.

A total of 23 eyes of 19 patients with CNV received treatment with IVZ injections. The causes of CNV were as follows: high myopia (9), macular telangiectasia (4), central serous chorioretinopathy (3), choroidal osteoma (2), choroiditis (2), Best’s disease (2) and idiopathic (1).

During a mean follow-up period of 4±1.9 months, the median number of IVZ infections was 1 (range, 1 to 3) and the median treatment-free interval at the time of the final visit was 3 months (range, 1 to 8).

Mean BCVA improved from 0.67 LogMAR to 0.58 LogMAR (p=0.0507). Of the 23 eyes, nine (39 percent) had BCVA improvements of at least 0.1 LogMAR, 11 (48 percent) had stable BCVA (within 0.1 LogMAR of baseline) and three (13 percent) had a BCVA decline of at least 0.1 LogMAR at the final visit. From baseline until the final visit, the mean CMT significantly improved (22 vs 174.5 μm; p=0.037).

There were no ocular or systemic adverse events recorded, according to researchers.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.