Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Isolated maternal hypothyroxaemia in third trimester linked to pre-eclampsia

14 Jul 2017
Researchers in China have shown that isolated maternal hypothyroxaemia (IMH) detected during the third trimester of pregnancy is strongly correlated with pre-eclampsia in the first large-scale investigation to undertake long-term monitoring of free thyroxin (FT4) levels in Chinese mothers with hypothyroxaemia.

In the study, first (week 9–12) and third (week 32–36) trimester serum samples were collected from 6,031 mothers (aged 21–43 years) for analyses of thyroid function. All of the women had singleton pregnancies, were Han Chinese, had no history of thyropathy or autoimmune disease, no goiters, were thyroid peroxidase antibody (TPOAb)-negative, and did not use medicines that would affect thyroid hormone levels. In addition, all had TSH levels within the reference intervals during the first and third trimesters of pregnancy. Women were monitored for adverse pregnancy outcomes such as gestational diabetes mellitus (GDM), pregnancy-induced hypertension, and pre-eclampsia.

The researchers found that women who were older and those who had a higher pre-pregnancy body mass index were more likely to experience hypothyroidism. Although pregnancy-induced hypertension was not significantly correlated with FT4, GDM, and pre-eclampsia were inversely correlated with maternal FT4 levels during early and late pregnancy, respectively. In particular, women with IMH during the third trimester had an increased risk of developing pre-eclampsia.
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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.