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Iron supplements may reduce SBP in LBW children at 7 years

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Iron supplementation (1 or 2 mg Fe · kg−1· d−1) in low birth weight (LBW) children during infancy is associated with lower systolic blood pressure (SBP) at 7 years, a recent study has found.

To examine the effect of iron supplementation given to LBW infants on midchildhood BP, researchers conducted a randomized, double-blind, controlled trial including 285 marginally LBW (2,000 to 2,500 g) infants at two Swedish centres between May 2004 and November 2007.

Participants were randomly assigned to receive either placebo or 1 or 2 mg Fe · kg−1 · d−1 from 6 weeks to 6 months of age. Researchers then compared SBP, diastolic (D)BP and the prevalence of children with BP within the hypertensive range (>90th percentile) between the groups in secondary analyses at the age of 7 years.

Intention-to-treat analysis of BP was performed in 189 children (66 percent).

LBW children who received placebo (n=70), 1 mg Fe · kg−1 · d−1 (n=54) or 2 mg Fe · kg−1 · d−1 (n=65) had mean SBP of 103±8.1, 101±7.5 and 101±7.8 mm Hg, respectively. Combining the iron-supplemented group in covariate-adjusted analyses showed that children who received iron supplementation in infancy had a mean SBP of 2.2 mm Hg (95 percent CI, 0.3 to 4.2 mm Hg) lower than in those who did not receive supplementation (p=0.026).

Based on multivariate logistic regression analysis, the odds of having an SBP within the hypertensive range at the age of 7 years were reduced with iron supplementation in infancy (odds ratio, 0.32; 0.11 to 0.96). No significant differences in DBP were observed between the intervention groups.

“This novel observation [to our knowledge] suggests that the increased risk of hypertension that is observed in children and adults who are born small might be reduced with early micronutrient interventions,” researchers said.

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Most Read Articles
Radha Chitale, 19 May 2016
Women with atrial fibrillation (AF) are more symptomatic, more functionally impaired, and have worse quality of life compared with men with AF, although women are less likely to die, according to an observational cohort study comparing sex differences in AF.
01 Jun 2016
Valsartan plus amlodipine reduces albuminuria in chronic kidney disease (CKD) patients with hypertension, a randomised clinical trial showed.
27 May 2016

Women with genetically elevated body mass index (BMI) and blood glucose levels are more likely to have higher birth weight infants, while women with genetically elevated systolic blood pressure (SBP) are more likely to have lower birth weight infants, say UK-based researchers.

Elvira Manzano, 24 Jun 2015
Adding sitagliptin, a dipeptidyl peptidase 4 inhibitor (DPP-4), to usual care in patients with glycaemic equipoise does not increase the risk of cardiovascular (CV) events in patients with type 2 diabetes (T2D) and cardiovascular disease (CVD), according to the TECOS* study.