Most Read Articles
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.
Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.

Intraindividual variability of reaction time predicts all-cause mortality in elderly

22 Aug 2017
Having a greater number of nurses in gerontological nursing will help to better meet the needs of elderly patients.

Higher intraindividual variability of reaction time (IIVRT) predicts all-cause mortality independent of lower global cognition and prodromal dementia, a new study has found.

Over an 8-year follow-up period, the mortality rate in the cohort of 861 elderly adults was 22.2 percent (n=191). The mean survival time was 4.3±2.2 years.

Mean reaction time and median IIVRT were significantly lower in those who died (778.69±238.77 ms and 6.70, respectively) than in survivors (743.19±184.16 ms and 5.85, respectively; p<0.001 and p=0.001, respectively).

Moreover, general cognitive ability (-0.98±1.49 vs -0.43±1.20; p<0.001) was significantly lower in those who died, while cardiovascular disease (CVD) risk score (17.82±3.47 vs 16.97±3.37; p=0.003) was significantly higher.

While both IIVRT (hazard ratio [HR], 1.35; 95 percent CI, 1.15 to 1.59; p<0.001) and mean reaction time (HR, 1.36; 1.20 to 1.54; p<0.001) were significantly associated with all-cause mortality in unadjusted Cox models, only IIVRT remained a significantly predictor of all-cause mortality after adjusting for covariates in multivariate Cox regression models (HR, 1.22; 1.01 to 1.48; p=0.04).

Backward elimination from the fully adjusted model to obtain the best set of all-cause mortality predictors yielded a final model that showed IIVRT (HR, 1.22; 1.00 to 1.47; p=0.045), sex (HR, 1.78; 1.32 to 2.42; p<0.001) and age (HR, 1.13; 1.10 to 1.17; p<0.001) as the best set of predictors.

Notably, cognition scores were not significant predictors of all-cause mortality (HR, 0.88; 0.77 to 1.01; p=0.06).

Participants were recruited from the Sydney Memory and Ageing Study. Those with Mini-Mental State Scores ≤24, with baseline dementia or other neurological conditions and malignancy were excluded.

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Most Read Articles
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.
Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.