Most Read Articles
Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.
Roshini Claire Anthony, 28 Sep 2017

Intensive blood pressure (BP) lowering appears to reduce mortality risk during treatment in individuals with hypertension and moderate-to-advanced chronic kidney disease (CKD), findings from a recent systematic review and meta-analysis show.

21 Sep 2017
The risk of coronary heart disease (CHD), cerebrovascular disease and heart failure is greater among metabolically healthy obese than normal weight metabolically healthy individuals, suggests a recent study. Additionally, even those who are normal weight can have metabolic abnormalities and similar risks for cardiovascular disease (CVD) events.

Intracranial aneurysms, subarachnoid haemorrhage not linked to neurofibromatosis type 1

19 Jun 2017

There is no evidence to support the association between neurofibromatosis type 1 (NF1) and intracranial aneurysms (IA), a new population-based study shows. Moreover, there is no rise in the incidence of aneurysmal subarachnoid haemorrhage (aSAH) in NF1 patients.

The prevalence of NF1 was analysed in 4,543 unruptured IA or aSAH patients and their 19,644 first-degree relatives from the Kuopio IA Database. Only those with either fusiform or saccular IA and diagnosed from 1969 to 2015 were included.

Conversely, prevalence of unruptured IA and aSAH was analyzed in 1,410 NF1 patients and 14,030 corresponding controls obtained from the national NF1 registry of Finland; controls were matched by age, sex and place of residence. From both databases, clinical information, including medications received and cause of death were retrieved and included in the analysis.

There were a total of 156 diagnosed conditions potentially related to NF1 in the IA cohort. Of these, only two were diagnosed with NF1; however, one was tuberous sclerosis misdiagnosed as NF1. There was only one confirmed NF1 case in the entire cohort resulting in a prevalence of 22 per 100,000 cases.

Five other individuals were suspected to have NF1. However, one presented findings that indicated schwannomatosis, two were confirmed to have NF2, two had symptoms more suggestive of NF2 and the last was diagnosed with leiomyoma instead.

In the NF cohort, and over a mean follow-up period of 15.0 and 16.3 years for the NF1 patients and matched controls, respectively, there was only one reported case of unruptured IA determined from autopsies. There were no cases of unruptured IA in the NF1 cohort and 19 cases in the controls.

There were five and 34 diagnosed cases of SAH in the NF1 patients and controls, respectively (hazard ratio [HR], 1.8; 95 percent CI, 0.69 to 4.67; p=0.234). On the other hand, only one NF1 patient presented with aSAH.

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Most Read Articles
Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.
Roshini Claire Anthony, 28 Sep 2017

Intensive blood pressure (BP) lowering appears to reduce mortality risk during treatment in individuals with hypertension and moderate-to-advanced chronic kidney disease (CKD), findings from a recent systematic review and meta-analysis show.

21 Sep 2017
The risk of coronary heart disease (CHD), cerebrovascular disease and heart failure is greater among metabolically healthy obese than normal weight metabolically healthy individuals, suggests a recent study. Additionally, even those who are normal weight can have metabolic abnormalities and similar risks for cardiovascular disease (CVD) events.