Most Read Articles
09 Oct 2017
Pleural fluid lactic dehydrogenase (LDH) and glucose are useful parameters for evaluating severity of paediatric community acquired complicated pneumonia (PCACP), according to a study. Measurements of both parameters strongly correlate with prolonged hospitalization as an indirect indicator of disease severity.
5 days ago
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
6 days ago
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
Elaine Tan, 14 Aug 2017

Complicated and uncomplicated urinary tract infections (UTIs) in adults and children should be managed by identifying and treating predisposing or underlying risk factors, with antimicrobial treatment, if needed, based on urine culture results and regional antibiotic resistance patterns, according to new guidelines of the Urological Association of Asia (UAA) and Asian Association of UTI and STD (AAUS).

Inflammatory response involved in human anaplasmosis pathophysiology

27 Sep 2017
The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.

Proinflammatory responses and immune dysfunction may play a role in the pathophysiology and severity of human anaplasmosis (HA), reveals a recent study.

The study included 80 HA patients (mean age 54.2±20.1 years; 62.5 percent male) and 1,000 healthy controls (mean age 64.3±11.3 years; 43.9 percent male). Concentrations of cytokines were measured in serum samples collected from the participants.

Levels of interferon gamma (IFN-γ; 5.00 vs 0.571 pg/mL; p<0.0001), interleukin (IL)-10 (3.70 vs 1.055 pg/mL; p<0.0001), IL-12p70 (1.79 vs 0.297 pg/mL; p<0.0001), IL-1β (0.55 vs 0.101 pg/mL; p<0.0001), IL-8 (3.67 vs 1.707 pg/mL; p<0.0001), tumour necrosis factor-α (TNF-α; 2.89 vs 1.585 pg/mL; p<0.0001) and IL-6 (2.34 vs 0.849 pg/mL; p<0.0001) were significantly higher in HA patients than in controls.

Vomiting and diarrhoea were significantly associated with elevated levels of IL-13 and IL-5 (p≤0.023 for both), while thrombocytopoenia was correlated with higher levels of IL-10, IL-1β, IL-8, IL-6 and IFN-γ (p≤0.031 for all).

IFN-γ, IL-12p70 and Il-2 were all significantly elevated in patients who were in the earliest stages of the disease and who were ill for at most 4 days (p≤0.048 for all). In contrast, those who were hospitalized had significantly higher concentrations of IL-19 and TNF-α (p≤0.036).

HA patients with morulae on blood smears also had significantly higher IL-1β, IL-6 and IL-10 concentrations in the serum samples (p≤0.03). On the other hand, there were no significant differences in the serum cytokine levels between sexes or among age groups. 

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Most Read Articles
09 Oct 2017
Pleural fluid lactic dehydrogenase (LDH) and glucose are useful parameters for evaluating severity of paediatric community acquired complicated pneumonia (PCACP), according to a study. Measurements of both parameters strongly correlate with prolonged hospitalization as an indirect indicator of disease severity.
5 days ago
Use of systemic antibiotics, in conjunction with performance of incision and drainage, in the management of paediatric acute skin and soft tissue infection (SSTI) appears to reduce Staphylococcus aureus colonization and the likelihood of infection recurrence, a prospective study has found.
6 days ago
Retreatment with ledipasvir and sofosbuvir with add-on ribavirin appears to be effective and well tolerated in genotype 1 hepatitis C virus (HCV)-infected patients who have failed to respond to daclatasvir/asunaprevir combination therapy, according to a study.
Elaine Tan, 14 Aug 2017

Complicated and uncomplicated urinary tract infections (UTIs) in adults and children should be managed by identifying and treating predisposing or underlying risk factors, with antimicrobial treatment, if needed, based on urine culture results and regional antibiotic resistance patterns, according to new guidelines of the Urological Association of Asia (UAA) and Asian Association of UTI and STD (AAUS).