Most Read Articles
2 years ago
Catecholamines may regulate serum HDL cholesterol level, abdominal visceral and subcutaneous fat mass in men with pheochromocytoma, based on a cross-sectional and longitudinal follow-up study.
Christina Lau, 2 years ago
The rate of intermediate- and high-risk prostate cancer, defined as a prostate-specific antigen (PSA) level greater than 10 ng/mL, has increased in the US between 2011 and 2013.
Kathlin Ambrose, 2 years ago

The most appropriate form of treatment for moderate to severe cancer pain is opioid analgesia, but less than 15 percent of Malaysian patients with cancer pain receive this treatment, says Dr Mary Cardosa, consultant anaesthetist and pain management specialist, Hospital Selayang. 

2 months ago

LY2787106, a novel fully humanized monoclonal antibody (mAb) with high affinity for hepcidin, is a well tolerated and effective therapy for regulating iron levels in cancer patients with anaemia, say US-based researchers.

Infections predict death in diffuse large B cell lymphoma

10 days ago
GIS, CSI make first collaborative discovery on cancer progression

Diffuse large B cell lymphoma (DLBCL) patients with neutropenia and multiple comorbidities have a high risk of death and infection, a new study reports. Moreover, infection is an independent predictor of survival.

In a cohort of 325 DLBCL patients, Charlson Comorbidity Index (CCI) scores of 3 to 5 (hazard ratio [HR], 2.16; 95 percent CI, 1.71 to 2.74; p<0.001) and ≥6 (HR, 3.91; 2.34 to 6.28; p<0.001) were significantly correlated with infections.

Having Eastern Cooperative Oncology Group (ECOG) scores of 1 (HR, 2.09; 1.46 to 3.01; p<0.001), 2 (HR, 3.33; 2.22 to 5.04; p<0.001) and 3 (HR, 3.36; 1.99 to 5.66; p<0.001), and neutropenia within 48 hours (HR, 2.46; 1.91 to 3.17; p<0.001) were also associated with increased risks of infection.

Over the study duration of 10 years, 99 deaths (30.5 percent) were reported. The median time from diagnosis to death was 273 (129 to 636) days. The most common cause of death was progressive lymphoma (58.6 percent), followed by infection (12.1 percent) and other cancers (5.5 percent).

CCI scores of 3 to 5 (HR, 4.34; 2.00 to 6.33; p<0.001) and ≥6 (HR, 7.36; 3.38 to 16.00; p<0.001), an ECOG status of 1 (HR, 2.61; 1.02 to 6.66; p=0.045) and 3 or 4 (HR, 7.16; 2.04to 25.06; p=0.002), and infection upon admission (HR, 3.27; 2.03 to 5.27; p<0.001) were all independent and significant predictors of survival.

Participants were recruited from Monash Health I Melbourne, Australia, and were receiving rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) or similar chemotherapies.

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Most Read Articles
2 years ago
Catecholamines may regulate serum HDL cholesterol level, abdominal visceral and subcutaneous fat mass in men with pheochromocytoma, based on a cross-sectional and longitudinal follow-up study.
Christina Lau, 2 years ago
The rate of intermediate- and high-risk prostate cancer, defined as a prostate-specific antigen (PSA) level greater than 10 ng/mL, has increased in the US between 2011 and 2013.
Kathlin Ambrose, 2 years ago

The most appropriate form of treatment for moderate to severe cancer pain is opioid analgesia, but less than 15 percent of Malaysian patients with cancer pain receive this treatment, says Dr Mary Cardosa, consultant anaesthetist and pain management specialist, Hospital Selayang. 

2 months ago

LY2787106, a novel fully humanized monoclonal antibody (mAb) with high affinity for hepcidin, is a well tolerated and effective therapy for regulating iron levels in cancer patients with anaemia, say US-based researchers.