Most Read Articles
22 May 2017
Chronic obstructive pulmonary disease (COPD) is currently the 10th commonest cause of death in Singapore, with a disease burden of 5.9 percent according to a 2015 population-based survey (EPIC-Asia survey) in Singapore. Pearl Toh spoke with Dr Augustine Tee, chief and senior consultant of the Department of Respiratory and Critical Care Medicine at Changi General Hospital (CGH) in Singapore, on how COPD is often underdetected in the primary care population as symptoms are not specific and diagnosis requires a combination of clinical risk factors, symptoms and spirometry testing.
15 Aug 2017
New drug applications approved by US FDA as of 1 - 15 August 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
04 Aug 2017
Chronic obstructive pulmonary disease (COPD) is the fourth cause of global mortality, with experts predicting a potential future rise in the prevalence rates of COPD. 
11 May 2016

In conjunction with World Asthma Day which falls on 3rd May 2016, MIMS Doctor speaks to a renowned respiratory medicine specialist, Dato' Dr. Hj Abdul Razak Abdul Muttalif, regarding the chronic airway disease.

Incident, pre-existing diabetes mellitus linked to poorer outcomes in COPD

17 Apr 2017
Air Pollution beyond COPD & asthma: Linked to increased cancer mortality

Diabetes mellitus (DM), whether incident or pre-existing, is associated with worse clinical outcomes in patients with chronic obstructive pulmonary disease (COPD), a new study shows.

The study involved 2,015 patients (70 percent male; mean age 62.7±12.0 years) in Taiwan’s Longitudinal Health Insurance Database who had been diagnosed with COPD during at least two outpatient visits within 12 months; those who were hospitalized were also included. Exclusion criteria included having asthma or type 1 DM during the study the period and being younger than 40 at COPD diagnosis.

All-cause mortality was the primary endpoint for all COPD patients. For those without pre-existing DM, development of DM was also a primary endpoint. DM diagnoses after entry into the cohort were designated as incident DM.

In the COPD cohort, the most common comorbodities were hypertension (50 percent), coronary artery disease (23 percent) and cerebrovascular disease (18 percent). Furthermore, 16 percent (n=332) had pre-existing DM.

Those with pre-existing DM had a higher proportion of hypertension, coronary artery disease, heart failure, cerebrovascular disease, dyslipidaemia and other comorbidities compared with those without.

Of the 670 deaths (33 percent) in the COPD cohort, those with pre-existing DM had higher probabilities of mortality (hazard ratio [HR], 1.244; 95 percent CI, 1.010 to 1.532; p=0.04). There were no additive effects between DM and hypertension (p=0.72), dyslipidaemia (p=0.91), cerebrovascular disease (p=0.30), heart failure (p=0.70) and coronary artery disease (p=0.75) on mortality.

The effects of incident DM were evaluated in 304 matched COPD patients. These patients also had higher risks of mortality (HR, 1.810; 1.363 to 2.403; p<0.001). Survival was poorer for those with incident DM (p=0.027).

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Most Read Articles
22 May 2017
Chronic obstructive pulmonary disease (COPD) is currently the 10th commonest cause of death in Singapore, with a disease burden of 5.9 percent according to a 2015 population-based survey (EPIC-Asia survey) in Singapore. Pearl Toh spoke with Dr Augustine Tee, chief and senior consultant of the Department of Respiratory and Critical Care Medicine at Changi General Hospital (CGH) in Singapore, on how COPD is often underdetected in the primary care population as symptoms are not specific and diagnosis requires a combination of clinical risk factors, symptoms and spirometry testing.
15 Aug 2017
New drug applications approved by US FDA as of 1 - 15 August 2017 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
04 Aug 2017
Chronic obstructive pulmonary disease (COPD) is the fourth cause of global mortality, with experts predicting a potential future rise in the prevalence rates of COPD. 
11 May 2016

In conjunction with World Asthma Day which falls on 3rd May 2016, MIMS Doctor speaks to a renowned respiratory medicine specialist, Dato' Dr. Hj Abdul Razak Abdul Muttalif, regarding the chronic airway disease.