Most Read Articles
7 days ago
Patients with rheumatoid arthritis (RA) appear to have a high prevalence of any carotid plaques and severe carotid plaques, with high titre of anticyclic citrullinated peptide (anti-CCP) antibodies a risk factor for severe carotid atherosclerotic plaque in RA, according to a study.
3 days ago
Power Doppler ultrasound (PDUS)-detected synovitis strongly predicts short-term flares among patients with psoriatic arthritis (PsA) in clinical remission, reports a new study.
Elaine Tan, 29 days ago

Tofacitinib, a first-in-class Janus kinase (JAK) inhibitor, shows promise as an oral treatment with quick onset of action and sustained efficacy in patients with psoriatic arthritis (PsA) who do not respond adequately to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). 

2 months ago
Dose frequency adjustment of intravenous tocilizumab seems to be an effective strategy for the management of rheumatoid arthritis (RA), suggests a recent study.

In vitro fertilization may be effectively done in women with SLE, APS

2 months ago

It is possible to safely and successfully perform in vitro fertilization (IVF) in women with systemic lupus erythematosus (SLE) or antiphospholipid syndrome (APS), suggests a recent study.

A retrospective study was conducted to describe women with SLE or APS who have had at least one IVF cycle. Researchers compiled and assessed data about complication and success rates for IVF.

A total of 37 women (median age 34 years; range, 26 to 46) with SLE (n=23, including eight with antiphospholipid antibodies), SLE with APS (n=4) or primary APS (n=10) underwent 97 IVF procedures (median number of IVF cycles, 2.6; range, 1 to 8). The infertility was female in origin in 43 percent of cases, male in 19 percent, mixed in 14 percent and unexplained in 24 percent.

There was no woman who had premature ovarian insufficiency due to cyclophosphamide. Patients were treated with hydroxychloroquine (72 percent), steroids (70 percent), azathioprine (3 percent), aspirin (92 percent) or low molecular weight heparin (62 percent).

There were 27 (28 percent) pregnancies, 23 live births among 26 neonates (three twin pregnancies), two miscarriages, and two terminations for trisomy 13 and 21. During follow-up, six spontaneous pregnancies occurred. A total of 26 women (70 percent) delivered at least one healthy child.

Complications happened in or after eight IVF cycles (8 percent): SLE flares in four (polyarthritis in three and lupus enteritis in one) and thromboembolic events in four others. One of the SLE flares was the initial sign of previously undetected SLE. In two other flares and two thrombosis, it was obvious that patients had poor treatment adherence.

There was no ovarian hyperstimulation reported, according to researchers.

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Most Read Articles
7 days ago
Patients with rheumatoid arthritis (RA) appear to have a high prevalence of any carotid plaques and severe carotid plaques, with high titre of anticyclic citrullinated peptide (anti-CCP) antibodies a risk factor for severe carotid atherosclerotic plaque in RA, according to a study.
3 days ago
Power Doppler ultrasound (PDUS)-detected synovitis strongly predicts short-term flares among patients with psoriatic arthritis (PsA) in clinical remission, reports a new study.
Elaine Tan, 29 days ago

Tofacitinib, a first-in-class Janus kinase (JAK) inhibitor, shows promise as an oral treatment with quick onset of action and sustained efficacy in patients with psoriatic arthritis (PsA) who do not respond adequately to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). 

2 months ago
Dose frequency adjustment of intravenous tocilizumab seems to be an effective strategy for the management of rheumatoid arthritis (RA), suggests a recent study.