Most Read Articles
Elvira Manzano, 17 Oct 2017
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
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Tristan Manalac, 3 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

In vitro fertilization may be effectively done in women with SLE, APS

17 May 2017

It is possible to safely and successfully perform in vitro fertilization (IVF) in women with systemic lupus erythematosus (SLE) or antiphospholipid syndrome (APS), suggests a recent study.

A retrospective study was conducted to describe women with SLE or APS who have had at least one IVF cycle. Researchers compiled and assessed data about complication and success rates for IVF.

A total of 37 women (median age 34 years; range, 26 to 46) with SLE (n=23, including eight with antiphospholipid antibodies), SLE with APS (n=4) or primary APS (n=10) underwent 97 IVF procedures (median number of IVF cycles, 2.6; range, 1 to 8). The infertility was female in origin in 43 percent of cases, male in 19 percent, mixed in 14 percent and unexplained in 24 percent.

There was no woman who had premature ovarian insufficiency due to cyclophosphamide. Patients were treated with hydroxychloroquine (72 percent), steroids (70 percent), azathioprine (3 percent), aspirin (92 percent) or low molecular weight heparin (62 percent).

There were 27 (28 percent) pregnancies, 23 live births among 26 neonates (three twin pregnancies), two miscarriages, and two terminations for trisomy 13 and 21. During follow-up, six spontaneous pregnancies occurred. A total of 26 women (70 percent) delivered at least one healthy child.

Complications happened in or after eight IVF cycles (8 percent): SLE flares in four (polyarthritis in three and lupus enteritis in one) and thromboembolic events in four others. One of the SLE flares was the initial sign of previously undetected SLE. In two other flares and two thrombosis, it was obvious that patients had poor treatment adherence.

There was no ovarian hyperstimulation reported, according to researchers.

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Most Read Articles
Elvira Manzano, 17 Oct 2017
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 3 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.