Most Read Articles
3 years ago

Over the past few decades, there has been widespread concern about the increasing proportion of births born by caesarean delivery. The rising rate of primary caesarean section has led to the increased number of obstetric population with a history of prior caesarean delivery. Although this group of women may be offered planned vaginal birth after previous caesarean section (VBAC) or elective repeat caesarean section (ERCS), the VBAC rate is generally low particularly in well-developed countries. In the United States, the VBAC rate has decreased to 8.5% by 2006, while the total caesarean rate has increased to 31.1%.1

one year ago
Kidney and bladder stones (urinary tract stones) are not risk factors for osteoporosis in postmenopausal women, according to the women’s health initiative.
Lianne Cowie, 3 years ago

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one year ago
A study on participants from the Women's Health Initiative showed the dissociation between calcium/vitamin D supplementation and reduction in menopausal symptoms.

Hypnosis, venlafaxine equally reduce hot flashes; combination not superior to either approach

2 months ago

Hypnosis may produce reductions in hot flashes similar to that achieved with venlafaxine, according to a study, although the combination of these two treatment approaches is not superior to either treatment alone.

The pilot study randomized 71 postmenopausal women to one of four treatment groups: venlafaxine 75 mg plus hypnosis (VH; n=15; mean age 56 years), venlafaxine 75 mg plus sham hypnosis (VSH; n=19; mean age 54 years), placebo pill plus hypnosis (PH; n=22; mean age 54 years) and placebo pill plus sham hypnosis (PSH; n=15; mean age 56 years). Treatment lasted 8 weeks.

All women kept a daily diary in which hot flash severity and frequency were recorded in real time. A General Estimating Equation model facilitated analysis of intrapatient difference in hot flash score (frequency x severity) at 8 weeks—the primary endpoint—using VSH as the referent arm and controlling for baseline hot flashes.

The primary endpoint did not statistically differ in the active treatment arms, PH and VH, when compared with the referent arm VSH (p=0.34 and p=0.05, respectively). Hot flashes decreased by about 50 percent in the PH and VH arms vs 25 percent in the PSH arm. Women in the PSH arm also reported statistically smaller reductions in hot flash score compared with those in the referent VSH arm (p=0.001).

No significant negative side effects were reported during the course of the study.

Hot flashes occur commonly in menopause, affecting up to 75 percent of women including those with a history of cancer. The symptom can be a significant source of bother and distress, negatively affecting quality of life and possibly leading to a loss of productivity. [Lancet 2002;360:1851-1861; Clin Obstet Gynaecol 2007;21:261-274; Climacteric 2015;18:456-469]

Aside from hormonal therapy and nonhormonal alternatives such as serotonergic antidepressants and the anticonvulsant gabapentin, behavioural therapy also shows potential in the management of hot flashes. [N Engl J Med 2016;374:803-806; J Clin Oncol 2002;20:1578-1583; Oncol 2009;27:2831-2837]

The current data provide evidence of the efficacy of hypnosis in the treatment of hot flashes, although more studies are needed to elucidate whether the intervention could be combined with a different low-dose pharmacologic intervention “to provide optimal relief of hot flashes synergistically without ceiling effects and without side effects, or to identify a population who could benefit more from such a combination,” researchers said.

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Most Read Articles
3 years ago

Over the past few decades, there has been widespread concern about the increasing proportion of births born by caesarean delivery. The rising rate of primary caesarean section has led to the increased number of obstetric population with a history of prior caesarean delivery. Although this group of women may be offered planned vaginal birth after previous caesarean section (VBAC) or elective repeat caesarean section (ERCS), the VBAC rate is generally low particularly in well-developed countries. In the United States, the VBAC rate has decreased to 8.5% by 2006, while the total caesarean rate has increased to 31.1%.1

one year ago
Kidney and bladder stones (urinary tract stones) are not risk factors for osteoporosis in postmenopausal women, according to the women’s health initiative.
Lianne Cowie, 3 years ago

Tumor necrosis factor (TNF)-α inhibitors are commonly used in the treatment of inflammatory bowel disease (IBD), but the effects of these agents on pregnancy outcomes remain unclear. Now, a systematic review of the English literature has indicated that they pose little risk to the mother or her infant, even if use is continued through the third trimester.

one year ago
A study on participants from the Women's Health Initiative showed the dissociation between calcium/vitamin D supplementation and reduction in menopausal symptoms.