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Hypertension ups risk of developing open-angle glaucoma

2 months ago

Open-angle glaucoma (OAG) is more likely to occur in patients diagnosed with systemic hypertension (HTN) than those without HTN, according to a recent study.

An 11-year nationwide cohort study was conducted to assess the association between OAG and HTN. Included were patients with HTN and a matched comparison cohort from the Korean National Health Insurance Service National Sample Cohort database.

The HTN group consisted of patients who were prescribed antihypertensive medication, or those with systolic blood pressure (SBP) of at least 140 mm Hg or diastolic blood pressure (DBP) of at least 90 mm Hg. The OAG group was composed of patients satisfying the OAG criteria during repeated visits to an ophthalmologist.

Researchers used the Charlson comorbidity index to control for systemic conditions and performed Cox proportional hazard regression analysis.

OAG occurred in 1,961 (2.0 percent) patients in the HTN group and in 1,692 (1.7 percent) in the comparison group (p<0.001). The respective OAG incidence rates in patients with and without HTN were 19.0 and 16.4 per 10,000 person-years.

Based on multivariable Cox model, there was an association between HTN and an increased OAG incidence (adjusted hazard ratio [HR], 1.16; 95 percent CI, 1.09 to 1.24).

Subsequent OAG was more likely to occur in participants with higher SBP (adjusted HR, 1.12 for 120 to 139 mm Hg group; and adjusted HR, 1.20 for ≥140 mm Hg group) than in those who had SBP of <120 mm Hg. In addition, similar trends were seen in participants with higher DBP (adjusted HR, 1.11 for 80 to 89 mm Hg group; and adjusted HR, 1.07 for ≥90 mmHg group) and those with <80 mm Hg DBP.

A study by Newmann-Casey et al had similar observations, which found an increased hazard of developing OAG in individuals with HTN (HR, 1.17; 1.13 to 1.22) or diabetes mellitus (HR, 1.35; 1.21 to 1.50) or in combination (HR, 1.48; 1.39 to 1.58) relative to those without these conditions. [Ophthalmology 2011;118:1318-26]

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Most Read Articles
6 days ago
Obesity has a slight and substantial negative impact on the cognitive functioning of healthy individuals and major depressive disorder patients (MDD), respectively, a new study shows.
10 days ago
Increased serum levels of C-X-C motif chemokine (CXCL)-11, CXCL-9, CXCL-10 and interferon (IFN)-γ are associated with clinical manifestations of adult-onset Still’s disease (AOSD), reports a new study.
4 days ago
Myopia is associated with depressive symptoms in Chinese adults, a new population-based study shows.
4 days ago
Chronic obstructive pulmonary disease (COPD) is currently the 10th commonest cause of death in Singapore, with a disease burden of 5.9 percent according to a 2015 population-based survey (EPIC-Asia survey) in Singapore. Pearl Toh spoke with Dr Augustine Tee, chief and senior consultant of the Department of Respiratory and Critical Care Medicine at Changi General Hospital (CGH) in Singapore, on how COPD is often underdetected in the primary care population as symptoms are not specific and diagnosis requires a combination of clinical risk factors, symptoms and spirometry testing.