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Hyperkalaemia on admission tied to higher mortality in heart failure

02 Oct 2017

Serum potassium concentrations greater than 5.5 mEq/L at admission is independently correlated with elevated short- and long-term mortality in heart failure (HF) patients, a recent study suggests.

The study included 4,031 heart failure patients, 83 percent (n=3,349) of whom had low-normal potassium levels at admission, 11 percent (n=461) had borderline-high levels and 6 percent (n=221) had hyperkalaemia. Patients without serum potassium measurements at admission were excluded.

Hyperkalaemia patients had significantly higher unadjusted 30-day mortality rates compared with low-normal potassium patients (13 vs 7 percent; p=0.002). However, after adjusting for comorbidities, gender and age, the significant relationship was attenuated (hazard ratio [HR], 1.57; 95 percent CI, 0.73 to 3.35).

According to Kaplan-Meier survival analysis, hyperkalaemia and borderline-high potassium patients had significantly higher rates of 1-year all-cause mortality than those with low-normal potassium (40 vs 34 vs 27 percent, respectively; log rank p<0.01).

Adjusting for comorbidities, age and gender showed that only hyperkalaemia remained significantly related to 1-year mortality risk (HR, 1.51; 1.04 to 2.2), while borderline-high potassium levels did not (HR, 0.79; 0.57 to 1.09).

Ten-year all-cause mortality rates were also significantly higher in patients with hyperkalaemia and borderline-high potassium levels than in those with low-normal potassium levels (92 vs 88 vs 82 percent, respectively; log rank p<0.001). The difference between hyperkalaemia and borderline-high potassium level patients also reached significance (p=0.016).

Similarly, multivariate analysis adjusted for age, gender and comorbidities found that only hyperkalaemia was associated with higher all-cause mortality (HR, 1.31; 1.035 to 1.66; p=0.025), while borderline-high potassium was not (HR, 0.985; 0.83 to 1.16; p=0.86).

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
18 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
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Tristan Manalac, 20 hours ago
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