Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

HRQoL stable in glioblastoma patients after escalation 5-fraction stereotactic radiosurgery

27 Jul 2017

Health-related quality of life (HRQoL) remains constant in glioblastoma patients who underwent the prospective dose escalation trial of 5-fraction stereotactic radiosurgery with concurrent and adjuvant temozolomide, a new study shows.

The HRQoL of 30 trial participants (median age 66 years; 50 percent male) was assessed using the QoL questionnaire core-30 (QLQ-C30) and QoL questionnaire-brain cancer specific (QLQ-BN20) modules of the European Organization for Research and Treatment of Cancer, and the M.D. Anderson Symptom Inventory-Brain Tumour (MDAST-BT) questionnaire.

The investigators found a significant reduction of 1.72 points per month from baseline in the communication deficit scale (p=0.008). The false discovery rate was calculated to be 7 percent which indicates that the result was true discovery.

Over a median follow-up of 13.5 months, 26 participants experienced disease progression yielding a 12-month cumulative incidence of 64 percent. Disease progression was significantly associated with communication deficit (p=0.01).

In contrast, there were no significant changes from baseline in terms of global QoL, physical, social and emotional functioning, motor dysfunction, future uncertainty, insomnia and fatigue.

The 12-month cumulative incidence of adverse radiation effects (AREs) was 28 percent (n=8), of which 75 percent (n=6) were symptomatic. AREs were not significantly associated with any of the measures of HRQoL.

Aside from communication deficits, HRQoL was stable in five long-term survivors with a median follow-up of 34.7 months.

All study participants had supratentorial glioblastoma and were treated with increasing doses of hypofractionated stereotactic radiosurgery. Four radiation doses were used: 25, 30, 35 and 40 Gy.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.