Most Read Articles
Jairia Dela Cruz, 23 days ago
Statins appear to have a dose-dependent association with the risk of tuberculosis (TB), with a nationwide population-based study showing that statin users have 47 percent lower incidence of TB compared with nonusers.
one month ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
Pearl Toh, 5 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.
7 days ago
Mesalazine is not superior to placebo in terms of preventing recurrence in patients with diverticulitis, according to data from two phase III trials.

Histopathologic classification reveals renal outcomes in AAV patients

3 months ago

Histopathologic classification appears to be useful in determining renal outcome in patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), suggests a recent study. Additionally, results of a meta-analysis shows that patients with focal class have the best outcome while those with sclerotic class have the worst.

“Renal vasculitis is one of the most common manifestations of AAV, and renal histology is a key predictor of the outcome,” researchers said.

A retrospective analysis was performed to validate the histopathologic classification, and a meta-analysis was conducted to evaluate its predictive value. A total of 186 patients with ANCA-associated renal vasculitis diagnosed at Ruijin Hospital were enrolled in the retrospective study. Meanwhile, data for 1,601 patients were considered for the meta-analysis.

Findings from the retrospective study revealed that patients with focal class had the best renal outcome, while those with mixed class had the worst (p<0.001). In the meta-analysis, patients with focal class had better renal outcome than did those with crescentic class (risk ratio [RR], 0.23; 95 percent CI, 0.16 to 0.34; p<0.00001), with no evidence of heterogeneity (I2=0 percent; p=0.96).

Moreover, patients with crescentic class had better renal outcome than did those with sclerotic class (RR, 0.52; 0.41 to 0.64; p<0.00001), with no evidence of heterogeneity (I2=2 percent; p=0.43). There was no statistically significant difference in the renal outcome between mixed and crescentic classes (RR, 1.14; 0.91 to 1.43; p=0.27), with no evidence of heterogeneity (I2=23 percent; p=0.19).

The most common extrarenal manifestations were lung and upper respiratory tract involvement, according to researchers.

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Most Read Articles
Jairia Dela Cruz, 23 days ago
Statins appear to have a dose-dependent association with the risk of tuberculosis (TB), with a nationwide population-based study showing that statin users have 47 percent lower incidence of TB compared with nonusers.
one month ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
Pearl Toh, 5 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.
7 days ago
Mesalazine is not superior to placebo in terms of preventing recurrence in patients with diverticulitis, according to data from two phase III trials.