Most Read Articles
4 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 5 days ago
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Yesterday
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
4 days ago
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.

Higher serum albumin level after PEG tube insertion predicts longer survival

16 Mar 2017

Survival after percutaneous endoscopic gastrostomy (PEG) tube insertion in elderly patients with severe dementia is potentially influenced by a higher serum albumin level at baseline and a stable/increased serum albumin level during follow-up, suggest a recent study.

Researchers enrolled 189 patients (aged ≥64 years) with severe dementia who underwent PEG tube insertion from 2002 to 2011 at a tertiary hospital and followed through 2014 to determine the factors affecting survival after such procedure. They collected data on background diseases, laboratory tests conducted 14 days before and 90 days after PEG, and date of death.

Multivariate Cox regression analysis was performed and cumulative survival curves plotted.

Patients who died ≤30 days after PEG (n=32; 16.9 percent) had significantly lower mean baseline serum albumin level than those who survived longer (2.9 vs 3.3 g/dL; p<0.001). Also, patients who survived 1 year after PEG (n=96; 50.8 percent) had significantly higher serum albumin level than those who died earlier (3.4 vs 3.1 g/dL; p=0.002). There were no significant differences in other laboratory parameters.

A serum albumin level above the median (3.3 g/dL) was the sole predictor of survival after adjustment for background diseases (hazard ratio [HR], 0.51; 95 percent CI, 0.37 to 0.72; p<0.001). A stable/increased serum albumin levels at 90 days after PEG resulted in longer survival in patients, compared with decreased levels.

After adjustment for age and background diseases, the only predictor of survival was a stable/increased albumin level at 90 days (HR, 0.59; 0.42 to 0.85; p=0.004).

These findings support a previous study which concluded the potential of serum albumin to predict early survival in individuals undergoing PEG tube placement. [JPEN J Parenter Enteral Nutr 1997;21:72-4]

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Most Read Articles
4 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 5 days ago
An 8-week regimen of sofosbuvir-velpatasvir-voxilaprevir combination is not noninferior to a 12-week regimen of sofosbuvir-velpatasvir for patients with chronic hepatitis C virus (HCV) infection, report two recent phase 3 open-label trials.
Yesterday
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
4 days ago
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.