Higher compliance in every other day blood glucose testing
Blood glucose testing every other day in patients with controlled gestational diabetes mellitus (GDM) resulted in higher testing compliance than every day testing, a new study has shown.
In contrast, the two testing schedules produced no difference in birth weight, gestational age at delivery, need for medical treatment and other clinical parameters.
The investigators randomized 293 pregnant women with GDM to be tested for blood glucose either every day (n=149; mean maternal age 29.5±4.9 years) or every other day (n=144; mean maternal age 30.7±5.2 years) for the remainder of the pregnancy.
For the primary outcome, there was no significant difference between the two groups in terms of birthweight (mean difference, -41; 90 percent CI, -137 to 54; p=0.48). The upper bound of the CI was below the specified value of 165 g, indicating that every other day testing was noninferior to every day testing.
The compliance to average weekly (88.8 vs 91.8 percent; p<0.01) and entire pregnancy (90.0 vs 91.3 percent; p=0.01) blood glucose testing was significantly higher in patients who were tested every other day as opposed to those who were tested every day.
In contrast, none of the other postrandomization factors showed significant differences. In particular, the need for medical treatment (relative risk [RR], 1.47; 95 percent CI, 0.96 to 2.24) and antenatal steroid administration (RR, 5.10; s0.60 to 43.2) was similar between groups.
There were also no differences in obstetric complications such as pre-eclampsia (RR, 0.64; 0.35 to 1.15) and chorioamnionitis (RR, 0.21; 0.02 to 1.85).