Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 4 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
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High vitamin D levels may prevent death in patients with CKD

16 Jul 2017

Higher serum levels of 25-hydroxyvitamin D (25[OH]D) may likely reduce the risk of all-cause mortality in patients with chronic kidney disease (CKD), reports a study. However, evidence is inconclusive with regard to serum levels of >35 ng/mL.

To investigate the association between different levels of serum 25(OH)D and risk of all-cause mortality, researchers systematically searched Medline and Embase from inception to November 2016 for studies that reported risk estimates of all-cause mortality for three or more categories of serum 25(OH)D in patients with CKD. Also included were those that reported results as continuous.

A total of 1,281 studies were identified, of which 13 prospective cohort studies, two retrospective cohort studies and one nested case-control study were included. These involved 17,053 patients and 7,517 incident deaths.

The authors used a random-effects models to combine reported risk estimates. Summary risk estimates of all-cause mortality were 1.63 (95 percent CI, 1.32 to 1.94) for severe vitamin D deficiency (<10 ng/ml), 1.22 (1.09 to 1.35) for mild deficiency (10 to 20 ng/mL) and 1.12 (1.06 to 1.18) for insufficiency (20 to 30 ng/mL). These findings were more evident in dialysis-dependent patients.

A 10-ng/mL increase in serum 25(OH)D was associated with a 21-percent decrease in the risk of overall mortality (relative risk, 0.79; 0.70 to 0.87). There was also a lower risk of all-cause mortality at a serum 25(OH)D of 25 to 30 ng/mL. One of the sources of variation between studies was dialysis treatment.

Patients with CKD have a high prevalence of vitamin D deficiency, according to researchers.

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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 4 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
6 days ago
Blood glucose testing every other day in patients with controlled gestational diabetes mellitus (GDM) resulted in higher testing compliance than every day testing, a new study has shown.