Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

High low-carbohydrate diet scores up risk of diabetes mellitus

21 Jul 2017
There are many much beloved sources of carbohydrates we can taste, according to new findings

Compared with the lowest scores, the highest low-carbohydrate diet (LCD) scores are associated with a 17 percent higher risk of diabetes mellitus (DM), according to a new meta-analysis.

A meta-analysis of four eligible cohort studies (n=8,018) reporting on the effects of LCD on the risk of DM showed that the highest LCD scores had significantly higher risks of DM than the lowest scores (overall relative risk [RR], 1.17; 95 percent CI, 0.90 to 1.51; p=0.001).

Subgroup analysis was performed because of the high degree of heterogeneity (p<0.001). Adjustment for energy also yielded a correlation between DM risk and high LCD scores (RR, 1.32; 1.17 to 1.49) and removed heterogeneity (p=0.96).

Studies with follow-up periods of ≤12 years showed a significant association between risk of DM and high LCD scores (RR, 1.35; 1.05 to 1.75). Moreover, studies with quality scores <7 yielded significant correlations between DM risk and LCD scores (RR, 1.31; 1.15 to 1.49) while those with ≥7 quality scores did not (RR, 1.09; 0.73 to 1.63).

Studies for the meta-analysis were retrieved from PubMed, Google Scholar, ISI Web of Science, Embase and Scopus. The search yielded 14 original studies which were further reduced to four after excluding noncohort studies and those with irrelevant outcome reports.

One study focused on males, two on females and the remaining one on both sexes. Participants were aged anywhere from 13.8 to 75 years; follow-up duration ranged from 3.6 to 20 years.

The quality scores of the studies, measured by the Newcastle-Ottawa Scale, ranged from six to eight, indicating good- to high methodological quality in general.

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.