Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

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High-fibre diet reduces GI toxicity in patients undergoing pelvic radiotherapy

02 Oct 2017

Following a high-fibre diet during pelvic radiotherapy appears to lessen gastrointestinal (GI) toxicity both acutely and at 1 year compared with a habitual-fibre diet, a recent study has found.

Researchers randomized patients to either low-fibre (≤10 g nonstarch polysaccharide [NSP]/day; n=55), habitual-fibre (control; n=55) or high-fibre (≥18 g NSP/day; n=56) diets to assess the potentially beneficial mechanisms of fibre in preventing GI toxicity during pelvic radiotherapy. Participants received individualized counseling at the start of radiotherapy to achieve these targets.

The difference between groups in the change in the Inflammatory Bowel Disease Questionnaire–Bowel Subset (IBDQ-B) score between the starting and nadir (worst) score during treatment was the main outcome. Other measures included macronutrient intake, stool diaries and faecal short-chain fatty acid concentrations.

There were significant between-group differences in terms of fibre intakes (p<0.001). Although nonsignificant difference was observed between groups in the change in IBDQ-B scores between the start and nadir (p=0.093), the change in score between the start and end of radiotherapy was smaller in the high-fibre group (mean±SD, ‒3.7±12.8) than in the habitual-fibre group (‒10.8±13.5; p=0.011).

The difference in IBDQ-B scores at 1 year after radiotherapy was significant between the high-fibre (0.1±14.5) and the habitual-fibre (‒8.4±13.3) groups (p=0.004). There were no significant differences in stool frequency or form or in short-chain fatty acid concentrations.

Furthermore, significant decreases in energy, protein and fat intake were observed in the low- and habitual-fibre groups only.

“Restrictive, nonevidence-based advice to reduce fibre intake in this setting should be abandoned,” according to researchers.

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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.