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High-dose interleukin-2 offers complete response to patients with metastatic renal cell carcinoma

18 Aug 2017

There are independent patient responses to high-dose interleukin-2 and to targeted agents before and after receiving high-dose interleukin-2, according to a recent study. This suggests that carefully selected patients must be given high-dose interleukin-2 for the possibility of a complete and durable response without the fear of limiting the treatment benefit of targeted agents.

Researchers retrospectively reviewed the records of patients with metastatic renal cell carcinoma treated with high-dose interleukin-2 between July 2007 and September 2014 to assess survival outcomes. Clinicopathological data were abstracted and patient response to therapy was based on Response Evaluation Criteria In Solid Tumors (RECIST), version 1.1 criteria.

The authors used the Kaplan-Meier method to estimate progression-free and overall survival in the entire cohort, the response to high-dose interleukin-2 with regard to previous targeted agent therapy, and the response to the targeted agent in relation to the response to high-dose interleukin-2.

Of the 92 patients included in the study, 87 had documentation of a response to high-dose interleukin-2. Median overall survival from the initiation of high-dose interleukin-2 therapy in the entire cohort was 34.4 months.

Overall survival (median 34.4 and 30.0 months; p=0.88) and progression-free survival (median 1.5 and 1.7 months; p=0.8) were similar between patients who received targeted therapy before high-dose interleukin-2 and those who received no prior therapy, respectively.

In addition, patients with a complete or partial response to high-dose interleukin-2 had similar outcomes for subsequent targeted agents vs patients whose best response was stable or progressive disease (median overall survival, 30.1 vs 25.4 months; p=0.4).

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
18 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 20 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.