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High dietary phosphorus density ups risk of CKD in patients with DM

01 Aug 2017

An association exists between high dietary phosphorus density and an increased risk of developing chronic kidney disease (CKD) in diabetes mellitus (DM) patients with normal renal function, a recent study has found.

Researchers retrieved data from the Korean Genome and Epidemiology Study to assess the impact of dietary phosphorus density, defined as the ratio of a single-day dietary phosphorus amount to the total daily calorie intake, on the development of incident CKD in a cohort of individuals with normal renal function.

Included in the final analysis were 873 individuals with DM (mean age 55.6 years; 52.0 percent men) and 5,846 without DM (non-DM; mean age 51.4 years; 47.6 percent men) who were followed up biennially from 2001 to 2014. The primary endpoint of incident CKD is defined as a composite of estimated glomerular filtration rate <60 mL · min−1 · 1.73 m−2 and/or the development of proteinuria.

The mean estimated glomerular filtration rates were 91.6±14.0 mL · min−1 · 1.73 m−2 in the DM group and 94.5±14.0 mL · min−1 · 1.73 m−2 for the non-DM group. The mean values of dietary phosphorus density were 0.51±0.08 and 0.51±0.07 mg/kcal in the DM and non-DM groups, respectively.

There were 283 (32.4 percent) and 792 (13.5 percent) individuals who developed CKD in the DM and non-DM groups, respectively, during follow-up.

After dividing participants into quartiles according to the dietary phosphorus density in each group, the highest quartile correlated with the development of incident CKD by multiple Cox proportional hazard analysis in the DM group (p=0.02) but not in the non-DM group (p=0.72).

Researchers suggested the need to test the causality in this association in a randomized controlled trial.

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Most Read Articles
Elvira Manzano, 2 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 6 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
4 days ago
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.