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Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
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Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

High dietary acid load may increase risk of total, cause-specific mortality

29 Jul 2017
Eating fruits as an adolescent has shown decreased risk of breast cancer into adulthood.

A high dietary acid load score appears to elevate the risk of total mortality and mortality from cardiovascular disease (CVD), particularly ischaemic heart disease (IHD), according to a recent study involving Japanese adults.

To investigate the association between dietary acid load and total and cause-specific mortality, researchers conducted a large-scale, population-based, prospective cohort study in Japan involving 42,736 men and 49,742 women (aged 45 to 75 years) who had no history of cancer, stroke, IHD or chronic liver disease at baseline.

A validated 147-item food-frequency questionnaire was used to evaluate dietary intake, while nutrient intake was utilized to derive potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. Death and cause of death were identified by using the residential registry and death certificates.

Researchers used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95 percent confidence intervals (Cis) for total and cause-specific mortality with adjustment for potential confounding variables.

A total of 12,993 deaths occurred during a median 16.9 years of follow-up. There was an association between a higher PRAL and higher total mortality (multivariable-adjusted HR for mortality for the highest vs the lowest quartiles of PRAL scores, 1.13; 95 percent CI, 1.07 to 1.18; p<0.001 for trend).

An association existed between such a score and mortality from CVD (HR, 1.16; 1.06 to 1.28) and particularly from IHD (HR, 1.16; 1.02 to 1.33). There were similar associations between NEAP score and total and cause-specific mortality.

Finally, PRAL score was not associated with cancer mortality.

“Diet-induced metabolic acidosis has been linked to cardiometabolic abnormalities including hypertension and type 2 diabetes,” researchers said.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.