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Elvira Manzano, 4 days ago
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High anti-CCP titre linked to severe carotid plaque in rheumatoid arthritis

20 Jul 2017

Patients with rheumatoid arthritis (RA) appear to have a high prevalence of any carotid plaques and severe carotid plaques, with high titre of anticyclic citrullinated peptide (anti-CCP) antibodies a risk factor for severe carotid atherosclerotic plaque in RA.

The study included 200 patients with RA and 202 matched healthy controls. Researchers analysed the carotid ultrasound, clinical data and cardiovascular risk factors for each individual. Atherosclerotic plaque was defined as an intima-media thickness of ≥1.1 mm. The severity of plaque was evaluated by the plaque score, which was calculated as the sum of the maximal thickness of all plaques in bilateral carotid arteries.

Carotid plaque was found to be more common in the RA group vs the control group (47.0 vs 36.1 percent; p=0.027), with plaque score being significantly higher among RA patients (p=0.032).

On logistic regression analysis, RA emerged as an independent risk factor for the presence of plaque (adjusted odds ratio, 1.68; 95 percent CI, 1.03 to 2.74). Compared with RA patients without plaque, those with plaque had significantly higher anti-CCP antibodies titre (315.8 vs 281.1 U/mL; p=0.005).

A multiple linear regression analysis demonstrated an association between anti-CCP antibody titre and plaque score among patients with RA.

The leading cause of mortality in RA is cardiovascular death, attributed to approximately half of the total deaths. Excess CV risk in this population may be explained by traditional risk factors such as hypertension, type 2 diabetes, smoking, hypercholesterolemia, obesity and physical inactivity. Carotid artery plaque, as identified using ultrasound, indicates very high CV risk and is reported to strongly predict incident cardiovascular event rates in both RA patients and non-RA controls. [Open Rheumatol J 2016;10:49–59; Arthritis Res Ther 2015;17:55]

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
20 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 22 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.