Most Read Articles
Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.
Roshini Claire Anthony, 28 Sep 2017

Intensive blood pressure (BP) lowering appears to reduce mortality risk during treatment in individuals with hypertension and moderate-to-advanced chronic kidney disease (CKD), findings from a recent systematic review and meta-analysis show.

21 Sep 2017
The risk of coronary heart disease (CHD), cerebrovascular disease and heart failure is greater among metabolically healthy obese than normal weight metabolically healthy individuals, suggests a recent study. Additionally, even those who are normal weight can have metabolic abnormalities and similar risks for cardiovascular disease (CVD) events.

High, low atherogenic index of plasma tied to all-cause mortality

03 Jun 2017

Both high and low values of the atherogenic index of plasma (AIP) are independently associated with all-cause mortality, a new study reveals.

Laboratory, clinical and demographic information of 1,174 end-stage renal disease (ESRD) patients (mean age 55.4±14.2 years; 61.4 percent male) undergoing peritoneal dialysis (PD) or haemodialysis (HD) were retrieved from the electronic database of the Clinical Research Center for ESRD in Korea. Those with incomplete information and underwent dialysis for less than 3 months were excluded.

Using fasting blood measurements of plasma triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C), the investigators calculated the AIP of the participants. Death events and the corresponding causes were recorded until 30 September 2015, the end of the follow-up period.

With a median AIP of 0.47 (0.26 to 0.66), the 1,174 participants were further divided into quintiles according to AIP. For the first to fifth quintiles, the corresponding median AIP were 0.06, 0.31, 0.47, 0.62 and 0.84. HD was administered to 740 patients, while PD was administered to 434.

Univariate logistic regression showed that PD (β, 0.046; 95 percent CI, 0.01 to 10.082; p=0.01) was significantly associated with higher AP values compared with HD. Similarly, diabetes mellitus (β, 0.053; 0.017 to 0.088), higher BMI (β, 0.024; 0.019 to 0.029) and higher log high-sensitivity C-reactive protein (hs-CRP; β, 0.022; 0.001 to 0.043; p=0.04) were all significantly associated with higher AIP.

Multivariate logistic regression validated the significant, independent relationship between AIP and PD (β, 0.057; 0.022 to 0.093; p=0.002), diabetes mellitus (β,0.044; 0.008 to 0.0794; p=0.02), BMI (β, 0.024; 0.018 to 0.029; p<0.001) and hs-CRP (β, 0.026; 0.004 to 0.047; p=0.02).

There were 170 death and 55 cardiovascular death events recorded over the mean follow-up period of 33.2±18.2 months. Corresponding incidences were lowest in the third quintile (8.9 and 3.0 percent, respectively) and highest in the fifth quintile (17.1 and 6.8 percent, respectively).

Using the third quintile as a reference, Cox regression showed that the first (hazard ratio [HR], 1.76; 1.02 to 3.03) and fifth (HR, 2.15; 1.26 to 3.65) AIP quintiles were independently associated with all-cause mortality, resulting in a U-shaped plot of HRs against AIP quintiles.

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Most Read Articles
Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.
Roshini Claire Anthony, 28 Sep 2017

Intensive blood pressure (BP) lowering appears to reduce mortality risk during treatment in individuals with hypertension and moderate-to-advanced chronic kidney disease (CKD), findings from a recent systematic review and meta-analysis show.

21 Sep 2017
The risk of coronary heart disease (CHD), cerebrovascular disease and heart failure is greater among metabolically healthy obese than normal weight metabolically healthy individuals, suggests a recent study. Additionally, even those who are normal weight can have metabolic abnormalities and similar risks for cardiovascular disease (CVD) events.