Most Read Articles
5 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 6 days ago
An 8-week regimen of sofosbuvir-velpatasvir-voxilaprevir combination is not noninferior to a 12-week regimen of sofosbuvir-velpatasvir for patients with chronic hepatitis C virus (HCV) infection, report two recent phase 3 open-label trials.
2 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
5 days ago
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.

Heart failure tied to poor renal outcome risk

07 Sep 2017
Scientists have created a gel that staves off heart failure after a heart attack

Heart failure (HF) is associated with higher risk of poor renal outcomes, such as incident chronic kidney disease (CKD) and rapid drop in estimated glomerular filtration rate (eGFR), in patients with normal kidney function, a new study reveals.

Baseline information and medication exposure and compliance of 156,743 US veterans were collected. All participants had eGFR 60 mL min-1 1.73 m-2 and congestive HF. Study outcomes were incident CKD, rate of kidney function decline and a composite of incident CKD and mortality.

Over a median follow-up of 7.6 years, a total of 361,488 CKD events in the cohort were recorded, yielding an event rate of 16.04 per 1,000 patient-years. The CKD event rate was higher in veteran HF patients (68.90 per 1,000 person-years) than in those without (14.48 per 1,000 person-years).

Multivariate analysis showed a positive association between incident CKD and HF (hazard ratio [HR], 2.12; 95 percent CI, 2.10 to 2.14).

For the composite outcome, 986,588 events were reported. The incidence rates were again higher in HF patients (164.66 per 1,000 person-years) than in non-HF veterans (40.20 per 1,000 person-years). A positive association between HF and the composite outcome was also calculated (HR, 2.06; 2.05 to 2.08).

The overall prevalence of rapid eGFR decline was 9.12 percent and was higher in patients with HF (21.69 percent) than in those without (8.56 percent). Rapid eGFR decline was also positively associated with incident CKD (HR, 2.13; 2.10 to 2.17).

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Most Read Articles
5 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 6 days ago
An 8-week regimen of sofosbuvir-velpatasvir-voxilaprevir combination is not noninferior to a 12-week regimen of sofosbuvir-velpatasvir for patients with chronic hepatitis C virus (HCV) infection, report two recent phase 3 open-label trials.
2 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
5 days ago
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.