Habitual snoring in early pregnancy ups risk of GDM, IGT
Obstructive sleep apnoea (OSA), or habitual snoring, appears to increase the risk of impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM) in women in their early pregnancy, a new study has shown.
In the study, 1,579 women (mean maternal age 33.8±4.1) in their early pregnancies were asked about their snoring frequency, while their corresponding IGT and GDM statuses were determined using the glucose challenge test and the oral glucose tolerance test.
The likelihood of IGT and GDM in relation to snoring frequency during early pregnancy was determined using multivariate adjusted logistic regression.
Of all the participants, 146 reported snoring “most or all of the time;” 243, “some of the time;” 316, “a little of the time;” and 874, “none of the time.” Significant among-group differences were calculated for age, ethnicity, smoking frequency and family history of diabetes.
After adjusting for maternal age, ethnicity, smoking during pregnancy, prepregnancy body mass index (BMI) and familial history of diabetes, participants who smoked “a little of the time” (adjusted odds ratio [OR], 1.65; 95 percent CI, 1.14 to 2.38), “some of the time” (adjusted OR, 1.42; 0.94 to 2.17) and “most or all of the time” (adjusted OR, 1.77; 1.10 to 2.86) had higher a higher of glucose intolerance than those who answered “none of the time” (p=0.008 for trend).
Similarly, the risk of GDM was higher in participants who answered “a little of the time” (adjusted OR, 1.68; 0.99 to 2.83), “some of the time” (adjusted OR, 1.31; 0.69 to 2.46) and “most or all of the time” (adjusted OR, 2.50; 1.34 to 4.67) than in those who answered “none of the time” (p=0.009 for trend) after the same adjustments but excluding prepregnancy BMI.