Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.

Growth hormone therapy does not elevate mortality in children with growth disorder

29 Sep 2017

Paediatric growth hormone (GH) treatment does not increase mortality in children with idiopathic GH deficiency, idiopathic short stature, Turner syndrome, short stature homeobox-containing gene (SHOX) deficiency, history of benign neoplasia or born small for gestational age, suggests a recent study.

However, there is an increase in mortality among children with prior malignancy and those with underlying serious non-GH-deficient medical conditions.

A prospective, multinational, observational study was conducted on children with growth disorders from 827 study sites in 30 countries to investigate mortality in children receiving GH treatment. The main outcome measures were standardized mortality ratios (SMRs) and 95 percent CIs using age- and sex-specific rates from the general population.

A total of 9,504 GH-treated patients were followed for ≥4 years (67,163 person-years of follow-up). Of these, 42 deaths were reported (SMR, 0.77; 95 percent CI, 0.56 to 1.05).

Patients with history of malignant neoplasia had significantly elevated SMR (6.97; 3.81 to 11.69), and those with other serious non-GH-deficient conditions had borderline elevated SMR (2.47; 0.99 to 5.09).

Children with history of benign neoplasia (SMR, 1.44; 0.17 to 5.20), idiopathic GH deficiency (SMR, 0.11; 0.02 to 0.33), idiopathic short stature (SMR, 0.20; 0.01 to 1.10), short stature associated with small for gestational age birth (SMR, 0.66; 0.08 to 2.37), Turner syndrome (SMR, 0.51; 0.06 to 1.83) or SHOX gene deficiency (SMX, 0.83; 0.02 to 4.65) had no elevated SMRs.

“Although paediatric growth hormone treatment is generally considered safe for approved indications, concerns have been raised regarding potential for increased risk of mortality in adults treated with GH during childhood,” according to researchers.

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Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.