Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Gender, stressful events, early parenthood predict adolescent suicidality

14 Aug 2017
Singapore teenage suicide rates highest in 15 years

Gender, stressful life events and early parenthood are strong predictors of adolescent suicidality, a new study has shown.

The study included datasets from two longitudinal studies: The National Longitudinal Survey of Children and Youth (NLSCY) and the Avon Longitudinal Survey of Parents and Children (ALSPAC). The final sample size was 4,700. A Classification and Regression Tree (CART) model was built from the NLSCY cohort and validated in the ALSPAC cohort.

The primary outcome of the study was positive responses to questions about suicidal thoughts. Secondary outcomes included antisocial behaviour, substance abuse, poor physical health, poor mental health, poor academic performance and participation in risky health behaviours.

The overall weighted prevalence of suicidal thoughts was 12.0 percent in NLSCY cohort. CART showed that gender was the most powerful predictor of suicidal ideation. Stressful life events were the strongest predictor in females while early parental age was the strongest predictor in males.

Single parenthood, blended family composition, exposure to parental smoking, parental medical problems, lack of breast feeding and parental use of over-the-counter medications were also important predictors of suicidality.

The sensitivity and specificity of the model was 22.7 (95 percent CI, 19.4 to 26.1) and 89.2 (88.4 to 90.0) percent, respectively, while its positive and negative predictive values were 17.8 (15.1 to 20.50) and 91.8 (91.2 to 92.6) percent, respectively.

Validation against the ALSPAC cohort yielded a sensitivity and specificity of 19.9 (16.9 to 22.8) and 88.0 (87.0 to 89.0) percent, respectively. The resulting corresponding positive and negative predictive values were 22.5 (19.2 to 25.8) and 86.3 (85.2 to 87.3) percent.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.