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Functional outcomes poorer in women than in men after ischaemic stroke

23 Sep 2017

While in-hospital mortality rate from ischaemic stroke is comparable between males and females, functional outcomes are poorer at discharge and at 6 months in females, a new study has shown.

In the study sample of 4,278 ischaemic stroke patients (mean age 69.9±12.12 years; 41.1 percent female), in-hospital mortality rates were found to be significantly elevated in females compared with males (p<0.01) based on univariate analysis.

However, after adjusting for age, risk factors and severity of stroke, the significant difference in mortality was attenuated (odds ratio [OR], 1.13; 95 percent CI, 0.66 to 1.93).

Univariate analysis also revealed that age >75 years elevated the risk of in-hospital mortality for females only, while stroke severity and increased intracranial pressure raised the risk for both sexes.

Multivariate analysis showed that cardioembolism stroke (OR, 0.35; 0.15 to 0.81; p=0.01) and atrial fibrillation (OR, 2.84; 1.38 to 5.85; p<0.01) significantly increased the risk of in-hospital mortality in females, but not in males.

Good outcomes 6 months after the stroke event were observed in 56.1 percent (n=1,813) of patients. Analysis by gender showed that only 47.4 percent (n=629) of females reported good outcomes as compared to 62.2 percent (n=1,184) of males. The difference reached statistical significance (p<0.01).

Old age (>75 years; p<0.01) significantly correlated with more severe strokes and hypertension (p=0.05) with poorer overall outcomes in females but not in males.

In contrast, diabetes mellitus significantly correlated with disease severity (p=0.04), neurological deterioration (p=0.05) and haemorrhagic transformation (p=0.03) in males only. Poor disease outcome was significantly associated with diabetes mellitus in both sexes (p<0.01 for both).

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Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
5 days ago
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.
4 days ago
The size and shape of a person’s face may predict sex drive and intended infidelity, research has shown.