Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
14 Oct 2017
In pregnant women, adherence to recommended dietary intake of fat and fibre is associated with a more beneficial and richer gut microbiota which, in turn, decreases levels of the inflammation marker glycoprotein acetylation (GlycA), a study has shown.

Functional network changes may predict Alzheimer’s disease in elders

11 Aug 2017
Brain tricks: The fact that déjà vu occurs so randomly and rapidly—and in individuals without a medical condition—makes it difficult to study, and why and how the phenomenon occurs is up to much speculation.

Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.

The investigators categorized 45 CN elderly adults (mean age 75.2±4.7 years) into two groups according to the presence of Aβ: those with Aβ deposits (CN+; n=13) and those without (CN-; n=32). All participants were subjected to neuropsychological batteries, MEG, magnetic resonance imaging (MRI), 11C-Pittsburgh compound B-positron emission tomography (PiB-PET) and 18F-fluorodeoxyglucose PET (FDG-PET).

Functional connectivity (FC) analysis using the MEG results showed that network connectivity between the precuneus was significantly diminished in the CN+ (0.443±0.024) than in the CN- (0.470±0.022; p<0.001) group.

In contrast, FC between the precuneus and right inferior parietal lobule was significantly greater in the CN+ group (delta band, 0.366±0.008; theta band, 0.288±0.015) than in the CN- group (delta band, 0.343±0.011; theta band, 0.265±0.009; p<0.001 for both bands).

FC between the precuneus and right inferior parietal lobule was significantly greater for the delta and theta bands in the CN+ (0.365±0.011 and 0.287±0.009, respectively) than in the CN- group (0.343±0.010 and 0.265±0.010, respectively; p<0.001 for both).

All of the FC variables were either positively or negatively significantly correlated with PiB mean standardized uptake value ratio within default mode networks indicating significant linear associations with cerebral amyloid depositions.

Notably, quantitative analyses of FDG-PET and MRI volumetric data showed that there was no significant difference between the CN+ and CN- groups. FDG-PET scores were not significantly correlated with FC values.

Editor's Recommendations
Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
14 Oct 2017
In pregnant women, adherence to recommended dietary intake of fat and fibre is associated with a more beneficial and richer gut microbiota which, in turn, decreases levels of the inflammation marker glycoprotein acetylation (GlycA), a study has shown.