Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.

Fructose substitution offers little impact on fasting blood glucose, insulin, triglycerides

17 Aug 2017

Individuals with impaired glucose tolerance or type 2 diabetes (T2D) may benefit from the substitution of fructose for glucose or sucrose in food or beverages, suggests a systematic review and meta-analysis.

Researchers searched Medline, Embase, the Cochrane Library, the WHO International Clinical Trials Registry Platform Search Portal and clinicaltrials.gov until 26 April 2016 to review the evidence for a reduction in fasting glycaemic and insulinaemic markers after chronic, isoenergetic replacement of glucose or sucrose in foods or beverages by fructose.

Included were randomized controlled trials of isoenergetic replacement of glucose, sucrose or both by fructose in adults or children with or without diabetes. The trials lasted ≥2 weeks and measured fasting blood glucose (FBG). Main outcome measures included FBG and insulin, fasting triglycerides, blood lipoproteins and glycated haemoglobin (HbA1c) and body weight.

There were 14 comparison arms from 11 trials, involving 277 patients, included in the meta-analysis. The length of the studies varied from 2 to 10 weeks (mean 28 days), while doses of fructose were between 40 and 150 g/day (mean 68 g/day).

In some subgroups, substituting fructose led to significantly but only slightly lowered FBG (−0.14 mmol/L; 95 percent CI, −0.24 to −0.036 mmol/L), HbA1c (‒10 g/L; ‒12.90 to ‒7.10 g/L impaired glucose tolerance; ‒6 g/L; ‒8.47; ‒3.53 g/L normoglycaemia), triglycerides (‒0.08 mmol/L; ‒0.14 to ‒0.02 mmol/L) and body weight (‒1.40 kg; ‒2.07 to ‒0.74 kg).

No effect was seen on fasting blood insulin or blood lipids, according to researchers, adding that high-quality studies in individuals with impaired glucose tolerance or T2D are warranted.

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Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.