Most Read Articles
12 days ago
Increased serum levels of C-X-C motif chemokine (CXCL)-11, CXCL-9, CXCL-10 and interferon (IFN)-γ are associated with clinical manifestations of adult-onset Still’s disease (AOSD), reports a new study.
4 days ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
6 days ago
Myopia is associated with depressive symptoms in Chinese adults, a new population-based study shows.
7 days ago
Chronic obstructive pulmonary disease (COPD) is currently the 10th commonest cause of death in Singapore, with a disease burden of 5.9 percent according to a 2015 population-based survey (EPIC-Asia survey) in Singapore. Pearl Toh spoke with Dr Augustine Tee, chief and senior consultant of the Department of Respiratory and Critical Care Medicine at Changi General Hospital (CGH) in Singapore, on how COPD is often underdetected in the primary care population as symptoms are not specific and diagnosis requires a combination of clinical risk factors, symptoms and spirometry testing.

Fragility fractures predict CVD events in individuals with rheumatoid arthritis

20 days ago

In men and women with rheumatoid arthritis (RA), fragility fractures are a risk factor for the development of cardiovascular disease (CVD) events and should warn clinicians to target these individuals for further screening and preventive strategies for CVD, suggests a recent study.

To determine whether a fragility fracture is associated with an increased risk of CVD in both women and men with RA, researchers analysed a population-based cohort with incident RA from 1955 to 2007 and compared it with age- and sex-matched non-RA participants. Fragility fractures and CVD events following the RA incidence/index rate were identified, along with relevant predictors.

Cox models were used to examine the link between fractures and the development of CVD, in which fractures and CVD risk factors were modeled as time-dependent covariates.

A total of 1,171 participants (822 women; 349 men) were included in each of the RA and non-RA cohorts. There were 406 and 346 fragility fractures and 286 and 225 CVD events over follow-up, respectively.

A significant increase existed in overall CVD risk for RA participants following a fragility fracture (hazard ratio [HR], 1.81; 95 percent CI, 1.38 to 2.37) but not for non-RA participants (HR, 1.18; 0.85 to 1.63). There were similar results for both women and men with RA.

RA patients are likely to have fragility fractures and CVD, each of which has been reported to increase risks of morbidity and mortality, according to researchers, adding that fragility fractures share similar risk factors for CVD but may occur at relatively younger ages in individuals with RA.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
12 days ago
Increased serum levels of C-X-C motif chemokine (CXCL)-11, CXCL-9, CXCL-10 and interferon (IFN)-γ are associated with clinical manifestations of adult-onset Still’s disease (AOSD), reports a new study.
4 days ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
6 days ago
Myopia is associated with depressive symptoms in Chinese adults, a new population-based study shows.
7 days ago
Chronic obstructive pulmonary disease (COPD) is currently the 10th commonest cause of death in Singapore, with a disease burden of 5.9 percent according to a 2015 population-based survey (EPIC-Asia survey) in Singapore. Pearl Toh spoke with Dr Augustine Tee, chief and senior consultant of the Department of Respiratory and Critical Care Medicine at Changi General Hospital (CGH) in Singapore, on how COPD is often underdetected in the primary care population as symptoms are not specific and diagnosis requires a combination of clinical risk factors, symptoms and spirometry testing.