Most Read Articles
one year ago
In-centre distributed pulse oral calcitriol seems to be effective, safe, and economical as a treatment option for secondary hyperparathyroidism in patients on haemodialysis, based on a study.
one year ago
Kidney and bladder stones (urinary tract stones) are not risk factors for osteoporosis in postmenopausal women, according to the women’s health initiative.
Roshini Claire Anthony, one year ago

Type 2 diabetes (T2D) appears to be much more aggressive in youths, with beta cell function deteriorating much more quickly than in adults with T2D even with combination treatment, suggested the TODAY* study, key findings of which were presented at the recent ASEAN Federation of Endocrine Societies (AFES) meeting.

Pearl Toh, 5 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.

Folic acid lowers risk of first stroke associated with diabetes

3 months ago

An association exists between an increased risk of first stroke and diabetes or a fasting blood glucose (FBG) ≥7.0 mmol/L in Chinese hypertensive adults, a recent study has found. In addition, folic acid treatment can reduce this elevated risk by 34 percent.

“Diabetes is a known risk factor for stroke, but data on its prospective association with first stroke are limited,” researchers said. “Folic acid supplementation has been shown to protect against first stroke, but its role in preventing first stroke in diabetes is unknown.”

To test these hypotheses, a post hoc analysis of the China Stroke Primary Prevention Trial was conducted. This analysis involved hypertensive adults (n=20,327) without a history of stroke or myocardial infarction, who were randomly assigned to a double-blind daily treatment with 10 mg enalapril and 0.8 mg folic acid (n=10,160) or 10 mg enalapril (n=10,167).

Researchers used Kaplan-Meier survival analysis and Cox proportionate hazard models to test the hypotheses with adjustment for pertinent covariables. Median treatment duration was 4.5 years.

A total of 616 participants experienced a first stroke (497 ischaemic strokes) during treatment. Compared with a low FBG concentration (<5.0 mmol/L), a high FBG concentration (≥7.0 mmol/L) or diabetes was associated with an elevated risk of first stroke (2.6 vs 6.0 percent; hazard ratio [HR], 1.9; 95 percent CI, 1.3 to 2.8; p<0.001).

Treatment with folic acid attenuated the risk of stroke across a wide range of FBG concentrations ≥5.0 mmol/L, but its benefit was more pronounced among patients with FBG concentrations ≥7.0 mmol/L or with diabetes (HR, 0.66; 0.46 to 0.97; p<0.05). A significant interactive effect of FBG and folic acid treatment was observed on first stroke (p=0.01).

Researchers noted that additional research is warranted to confirm these findings.

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Most Read Articles
one year ago
In-centre distributed pulse oral calcitriol seems to be effective, safe, and economical as a treatment option for secondary hyperparathyroidism in patients on haemodialysis, based on a study.
one year ago
Kidney and bladder stones (urinary tract stones) are not risk factors for osteoporosis in postmenopausal women, according to the women’s health initiative.
Roshini Claire Anthony, one year ago

Type 2 diabetes (T2D) appears to be much more aggressive in youths, with beta cell function deteriorating much more quickly than in adults with T2D even with combination treatment, suggested the TODAY* study, key findings of which were presented at the recent ASEAN Federation of Endocrine Societies (AFES) meeting.

Pearl Toh, 5 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.