Fluoride salts, strontium ranelate up bone mechanical properties in osteoporosis
Strontium ranelate and fluoride salts, both established as strategies to reduce the risk of fractures in osteoporosis patients, improved the mechanical properties of the iliac crest samples of treated osteoporosis patients compared to untreated ones, according to a new study presented at the 6th Asia-Pacific Osteoporosis Meeting (IOF Regionals 2016) held in Singapore.
For the study, a total of 37 participants were recruited; eight were osteoporosis patients who had not received prior treatment, nine were patients who had received fluoride treatment, nine were those who had received strontium ranelate treatment, and 11 were healthy controls with no bone disease.
From each of the participants, iliac crest biopsies were collected for the downstream analyses. Instrumental neutron activation analysis was performed to measure the concentrations of both strontium and fluoride in the iliac crest samples.
Proton-induced X-ray emission was performed to show the distribution of strontium, while 19F(p,α)16O nuclear reaction was used to visualize the distribution of fluoride in the bone samples.
To measure the degree of mineralization of the bone samples, quantitative backscattered electron imaging was performed. Finally, reference point indentation was used to evaluate the mechanical properties of the iliac crest samples.
From the measurements, it was found that the concentration of strontium in the samples correlated with the treatment period; that is, strontium was mostly found in the newly-formed bone. This was not the same for fluoride.
Further, bone samples from strontium- and fluoride-treated patients had lower cortical porosity compared with that from untreated patients. Healthy controls showed the lowest cortical porosity.
Similarly, quantitative backscattered electron imaging revealed that treatments led to stronger backscatter signals compared to the untreated patients. Healthy controls showed the strongest backscatter signals.
Finally, strontium- and fluoride-treated iliac crests showed lower indentation distances compared with untreated bone samples. Similarly, those from healthy controls showed the shortest indentation distances.
The findings show that fluoride salts and strontium ranelate treatment for patients diagnosed with osteoporosis can result in improved mechanical properties of the iliac crest.